Pediatric Hematology/Oncology and ImmunopathologyPediatric Hematology/Oncology and ImmunopathologyВопросы гематологии/онкологии и иммунопатологии в педиатрии1726-17082414-9314Fund Doctors, Innovations, Science for Children95810.24287/1726-1708-2025-24-1-199-206LITERATURE REVIEWОБЗОР ЛИТЕРАТУРЫModern concepts in the treatment of classical Hodgkin lymphoma in children and adolescentsСовременные представления о терапии классической лимфомы Ходжкина у детей и подростковhttps://orcid.org/0000-0002-2410-28672722-8515ShestopalovG. I.ШестопаловГ. И.
Russian Federation

Gleb I. Shestopalov - a hematologist of the Department of Bone Marrow Transplantation at the Russian Children's Clinical Hospital of the N.I. Pirogov Russian National Research Medical University of Ministry of Healthcare of the Russian Federation.

117 bldg. 1, Leninsky prospekt, 119571, Moscow

Шестопалов Глеб Игоревич - врач-гематолог отделения трансплантации костного мозга Российской детской клинической больницы – филиала ФГБУ РНИМУ им. Н.И. Пирогова Минздрава России.

119571, Москва, Ленинский проспект, 117, корп. 1

shestopalovgleb@yandex.ruhttps://orcid.org/0000-0002-2574-1636VolchkovE. V.ВолчковЕ. В.
Russian Federation

Moscow

Егор Васильевич Волчков

Москва

volchcov.egor@yandex.ruhttps://orcid.org/0000-0003-2801-7421EvstratovD. A.ЕвстратовД. А.
Russian Federation

Moscow

Дмитрий Андреевич Евстратов

Москва

evstratov.d.a@yandex.ruhttps://orcid.org/0000-0002-4779-1896MyakovaN. V.МяковаН. В.
Russian Federation

Moscow

Наталья Валериевна Мякова

Москва

nmiakova@mail.ruRussian Children's Clinical Hospital of the N.I. Pirogov Russian National Research Medical University of Ministry of Healthcare of the Russian FederationРоссийская детская клиническая больница – филиал ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииThe Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian FederationФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России080420252411992063101202525022025Copyright ©; 2025, «D. Rogachev NMRCPHOI»Copyright ©; 2025, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России2025«D. Rogachev NMRCPHOI»ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава Россииhttps://creativecommons.org/licenses/by/4.0https://hemoncim.com/jour/article/view/958

Over the past century, classical Hodgkin lymphoma (HL) has evolved from a fatal disease to one of the most curable cancers. Treatment protocols for pediatric patients with HL have been developed by the world's major research consortia: the Children's Oncology Group (COG) and the European Network-Paediatric HL Study Group (EuroNet-PHL). Their efforts are devoted to identifying ways to reduce the indications for radiation therapy and to use smaller field sizes and reduced doses of radiation therapy as well as lower doses of chemotherapy with the aim to reduce early mortality and potential toxicity in the long term. These protocols rely on risk-adapted treatment programs based on early response to chemotherapy, which has become a determining factor for the use of radiotherapy. Positron emission tomography has taken a leading role in staging and evaluation of treatment response. The aim of this review is to summarize current understanding of pediatric classical HL treatment according to the approaches of the COG and EuroNet-PHL research consortia.

За последнее столетие классическая лимфома Ходжкина (ЛХ) превратилась из фатального заболевания в один из самых излечимых видов рака. Педиатрические протоколы по лечению ЛХ созданы основными мировыми консорциумами: Детской онкологической группой (COG) и Европейской группой по лечению детской ЛХ (EuroNet-PHL) и уделяют основное внимание поиску подходов к ограничению показаний и уменьшению объемов лучевой терапии и доз химиотерапевтических препаратов, которые могут вызывать долгосрочную токсичность и стать причиной ранней летальности. В их основе лежат риск-адаптированные программы, основанные на раннем ответе на химиотерапию, что стало определяющим фактором для применения лучевой терапии. Ведущее место в стадировании заболевания и оценке ответа на терапию заняла позитронно-эмиссионная томография. Целью данного обзора является обобщение современных представлений о лечении детской классической ЛХ в соответствии с подходами консорциумов COG и EuroNet-PHL.

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