Внутриклеточная сигнализация при феномене запрограммированной гибели нейтрофилов с появлением внеклеточных ДНК-ловушек при тромбообразовании

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Формирование внеклеточных ДНК-ловушек нейтрофилов (NET-оз) является важной составляющей многих патологических процессов, относящихся к областям современной гематологии, онкологии и иммунологии. Этот механизм запрограммированной клеточной смерти нейтрофилов и других лейкоцитов оказался вовлечен и в патогенез тромбозов и тромботических осложнений многих заболеваний. В данном обзоре мы рассматриваем пути внутриклеточной сигнализации, ведущие к активации нейтрофилов в условиях тромбоза и гемостаза. Несмотря на то, что биохимические реакции в клетке изучены достаточно хорошо, в NET-оз оказываются вовлечены такие специфические белки, как NADPH-оксидаза (NOX) и пептидил-аргинин деиминаза (PAD4), регуляция активности которых изучена недостаточно. Отдельно рассматриваются существующие подходы к фармакологической модуляции NET-оза.

Об авторах

А. Н. Свешникова

ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России;
ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»;
ФГБУН «Центр теоретических проблем физико-химической фармакологии» РАН

Автор, ответственный за переписку.
Email: a.sveshnikova@physics.msu.ru
ORCID iD: 0000-0003-4720-7319

Свешникова Анастасия Никитична, д-р физ.-мат. наук, заведующая лабораторией клеточной биологии и трансляционной медицины ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева»

117997, Москва, ул. Саморы Машела, 1

Россия

Е. А. Адаманская

ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России;
ФГБУН «Центр теоретических проблем физико-химической фармакологии» РАН

ORCID iD: 0009-0000-4828-4063

Москва

Россия

Ю.-Д. Д. Коробкина

ФГБУН «Центр теоретических проблем физико-химической фармакологии» РАН

ORCID iD: 0000-0002-2762-5460

Москва

Россия

М. А. Пантелеев

ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России;
ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»;
ФГБУН «Центр теоретических проблем физико-химической фармакологии» РАН

ORCID iD: 0000-0002-8128-7757

Москва

Россия

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