Ommaya reservoir for intraventricular chemotherapy of children with neuro-oncological and oncohematological diseases: Design history, implantation technology, and experience gained at the Federal Research Center of Pediatric Hematology, Oncology, and Immunology named after Dmitry Rogachev

S. S. Ozerov; Озеров Сергей Сергеевич; A. V. Melnikov; Мельников Андрей Викторович; A. E. Samarin; Самарин Алексей Евгеньевич; G. V. Tereshchenko; Терещенко Галина Викторовна; E. V. Kumirova; Кумирова Элла Вячеславовна; N. V. Myakova; Мякова Наталья Валерьевна; N. S. Grachev; Грачев Николай Сергеевич; O. G. Zheludkova; Желудкова Ольга Григорьевна

doi:10.24287/1726-1708-2015-14-4-5-9

Ommaya reservoir for intraventricular chemotherapy of children with neuro-oncological and oncohematological diseases: Design history, implantation technology, and experience gained at the Federal Research Center of Pediatric Hematology, Oncology, and Immunology named after Dmitry Rogachev

Authors: Ozerov S.S.¹^,2, Melnikov A.V.², Samarin A.E.¹, Tereshchenko G.V.¹, Kumirova E.V.¹, Myakova N.V.¹, Grachev N.S.¹, Zheludkova O.G.³
Affiliations:
1. Federal Research Center of Pediatric Hematology, Oncology, and Immunology named after Dmitry Rogachev
2. Institute of Urgent Pediatric Surgery and Traumatology
3. Russian Center of Roentgenoradiology
Issue: Vol 14, No 4 (2015)
Pages: 5-9
Section: ONCOLOGY
Submitted: 19.09.2018
Published: 19.12.2015
URL: https://hemoncim.com/jour/article/view/116
DOI: https://doi.org/10.24287/1726-1708-2015-14-4-5-9
ID: 116

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Abstract

Ommaya reservoir is a convenient and reliable port for intraventricular injection of chemotherapeutic drugs in patients with oncohematological and neuro-oncological diseases. A total of 45 Ommaya reservoirs were implanted in 45 patients at the Federal Research Center of Pediatric Hematology, Oncology, and Immunology named after Dmitry Rogachev (Moscow) in 2012-2015. Because of small ventricles in most cases Ommaya reservoirs were implanted by stereotactic procedure. Intraventricular injection of methotrexate supported a high and stable concentration of the drug in the cerebrospinal fluid and proved to be a good alternative to intrathecal administration. In hydrocephalus Ommaya reservoir could be combined with pressure-regulated ventriculoperitoneal shunt, this providing a high concentration of methotrexate in the cerebrospinal fluid, safe for the patient.

Keywords

дети, опухоли головного мозга, онкогематологические заболевания, интравентрикулярная химиотерапия, резервуар Оммайя, метотрексат, children, brain tumors, oncohematological diseases, intraventricular chemotherapy, Ommaya reservoir, methotrexate

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Ommaya reservoir for intraventricular chemotherapy of children with neuro-oncological and oncohematological diseases: Design history, implantation technology, and experience gained at the Federal Research Center of Pediatric Hematology, Oncology, and Immunology named after Dmitry Rogachev

Full Text

Abstract

Keywords

About the authors

References

Supplementary files