Clinical manifestations and laboratory features of acute parvovirus infection in children with oncohematological diseases (Review of literature and clinical case reports)

A. A. Roppelt; Роппельт Анна Артуровна; A. P. Vasilyeva; Васильева Анна Петровна; I. I. Kalinina; Калинина Ирина Игоревна; D. D. Baidildina; Байдильдина Дина Дамировна; E. V. Suntsova; Сунцова Елена Викторовна; T. Yu. Salimova; Салимова Татьяна Юрьевна; U. N. Petrova; Петрова Ульяна Николаевна; I. V. Fisyun; Фисюн Иван Владимирович; E. V. Raikina; Райкина Елена Владиславовна; O. V. Goronkova; Горонкова Ольга Владимировна; M. A. Maschan; Масчан Михаил Александрович; A. A. Maschan; Масчан Алексей Александрович

doi:10.24287/1726-1708-2015-14-4-25-31

Clinical manifestations and laboratory features of acute parvovirus infection in children with oncohematological diseases (Review of literature and clinical case reports)

Authors: Roppelt A.A.¹, Vasilyeva A.P.¹, Kalinina I.I.¹, Baidildina D.D.¹, Suntsova E.V.¹, Salimova T.Y.¹, Petrova U.N.¹, Fisyun I.V.¹, Raikina E.V.¹, Goronkova O.V.¹, Maschan M.A.¹, Maschan A.A.¹
Affiliations:
1. Federal Research Center of Pediatric Hematology, Oncology, and Immunology named after Dmitry Rogachev
Issue: Vol 14, No 4 (2015)
Pages: 25-31
Section: CLINICAL OBSERVATIONS
Submitted: 19.09.2018
Published: 19.12.2015
URL: https://hemoncim.com/jour/article/view/119
DOI: https://doi.org/10.24287/1726-1708-2015-14-4-25-31
ID: 119

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Abstract

Parvovirus B19 (РВ19) is an ubiquitous single strand DNA-virus, which in healthy persons causes the so-called fifth disease -benign infectious exanthema. However, in patients with disturbed erythropoiesis or immune deficiencies PB19 infection can lead to potentially life-threatening syndromes. Three pediatric patients (females) with primary PB19 infection are described. One patient with hereditary spherocytosis developed a classical transitory aplastic crisis which required several blood transfusions. In a second patient with acquired aplastic anemia and high titers of PB19 in peripheral blood, long-lasting fewer, and rash hematopoietic stem cell transplantation had to be postponed for 2 weeks because of the risk of graft function suppression. In a third patient high titers of PB19 in bone marrow resulted in long-lasting aplasia and delay of scheduled intensive chemotherapy and hence, in relapse of underlying acute myeloid leukemia. Importantly that 2 of 3 patients (the second and the third one) received platelet transfusions from the same donor. So far, the problem of diagnosis, treatment and prevention of PB19 infection in patients with hematological/oncological diseases remains unresolved and needs further discussion.

Keywords

дети, острая парвовирусная инфекция, транзиторный апластический криз, гематологические заболевания, онкогематологические заболевания, children, acute parvovirus infection, transitory aplastic crisis, hematological diseases, oncohematological diseases

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Clinical manifestations and laboratory features of acute parvovirus infection in children with oncohematological diseases (Review of literature and clinical case reports)

Full Text

Abstract

Keywords

About the authors

References

Supplementary files