The role and place of haemopoietic stem cell transplantation in treatment of acute myeloid leukemia in children. A Belarus experience

The work was aimed at analysis of the role of haemopoietic stem cell transplantation in treatment of acute myeloid leukemia in children. The study included 151 patients with de novo acute myeloid leukemia and 39 patients with relapsed. Patients with de novo acute myeloid leukemia received programme treatment in the Republican Research and Practical Centre of Paediatric Oncology, Haematology and Immunology of the city of Minsk in the period from May 1999 to December 2013 according to original protocols AML-ММ-2000 and AML-ММ-2006. Patients with relapsed acute myeloid leukemia received treatment according to the international protocol AML-Relapsed 2001/01. Our analysis has shown that allogenic haemopoietic stem cell transplantation is absolutely indicated to patients with prognostically unfavourable molecular-genetic abnormalities in first remission and to all patients receiving second-line treatment. Patients of a favourable prognostic group have good results of treatment even without haemopoietic stem cell transplantation in first remission.

дети, острый миелоидный лейкоз, трансплантация гемопоэтических стволовых клеток, children, acute myeloid leukemia, haemopoietic stem cell transplantation