Perspectives of the practical use of molecular-genetic stratification of risk groups among children with medulloblastoma

Cover Page

Cite item

Full Text

Abstract

Genetic studies of the last ten years have lead to dramatic changes in the concept of the biology of medulloblastomas. It is now accepted that there are four genetic (molecular) groups of medulloblastomas: WNT (Wingless), SHH (Sonic Hedgehog), group 3 and group 4. These groups are significantly different as far asgene expression, disease stateand prognosis are concerned. Adequate treatment, including the use of targeted drugs, now imperatively requires stratification according to the new criteria. This article provides a systematic review of relevant latest research on this new stratification of medulloblastomas.

About the authors

Liudmila I. Papusha

Dmitry Rogachev Federal Research Center of Pediatric Hematology, Oncology and Immunology

Author for correspondence.
Email: Lyudmila.Papusha@fccho-moscow.ru
Russian Federation

Alexsandr G. Drui

Dmitry Rogachev Federal Research Center of Pediatric Hematology, Oncology and Immunology

Email: alexander.druy@fccho-moscow.ru
Russian Federation

Liudmila A. Yas'ko

Dmitry Rogachev Federal Research Center of Pediatric Hematology, Oncology and Immunology

Email: liudmila.yasko@fccho-moscow.ru
Russian Federation

Yulia V. Ol'shanskaya

Dmitry Rogachev Federal Research Center of Pediatric Hematology, Oncology and Immunology

Email: Yuliya.Olshanskaya@fccho-moscow.ru
Russian Federation

Ella V. Kumirova

Dmitry Rogachev Federal Research Center of Pediatric Hematology, Oncology and Immunology

Email: ella.kumirova@fccho-moscow.ru
Russian Federation

Galina A. Novichkova

Dmitry Rogachev Federal Research Center of Pediatric Hematology, Oncology and Immunology

Email: Galina.Novichkova@fccho-moscow.ru
Russian Federation

References

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2016 Papusha L.I., Drui A.G., Yas'ko L.A., Ol'shanskaya Y.V., Kumirova E.V., Novichkova G.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.