An immunological and genetic characteristic of malignant blood diseases in children

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Abstract

The article discusses the features and genetic regulation of cytokine lymphoproliferative inflammation on the background of a number of hematological malignancies. A total of 70 children (37 (53%) boys and 33 (47%) female), average age of 7,6 ± 2,59 years) with malignant blood diseases. Patients performed immunologic study cytokine status (IL-1 ß, IL-4, IL-10, TNF-a, IFN-y, receptor antagonist IL-1 (I_-1Ra)), and molecular genetic testing gene polymorphisms - immune response modifiers family interleukin-1 (IL1RN*VNTR gene polymorphism, IL1B (rs1143634)) and tumor necrosis factor (TNFA*G-308A (rs1800629)). _ Demonstrated high production major pro-inflammatory (IL-1 ß, IL-4, p - 0.001) and anti-inflammatory (IL-1Ra, IL-10, p - 0.001) cytokines in children with hematological malignancies in the development of febrile neutropenia, a significant increase in INF-y (p = 0.017) and TNF -a (p = 0.036) with a lethal outcome, as well as the maximum concentration of IL-1 ß (p = 0.001) and INF-y (p = 0.003) on the background of the development of nephropathy. We describe the association of genotype A2A2 and A2 allele gene IL1RN*VNTR with certain diseases (acute lymphoblastic leukemia, T-cell non-Hodgkin's lymphoma), their complications and adverse outcomes. The features of the genetic regulation of cytokine inflammation, so it has been shown that carriers of the genotype A2A2 IL1RN gene (VNTR) and genotype A2A2 IL1B gene (rs1143634) is characterized by high levels of IL-10 (p = 0.041, p = 0.027) among carriers of genotype GA gene TNFA*G-308A (rs1800629) reported high levels of TNF-a (p = 0.035). In general, it showed high activity of inflammation in hematological malignancies as increased pro- and antiinflammatory cytokines. The features of systemic inflammation cytokine regulation at individual nosological forms of leukemia and their complications.

About the authors

Elena I. Kondrateva

Kuban State Medical University; Medical Genetics Research Centre; Siberian State Medical University

Author for correspondence.
Email: Медикогенетического научного центра elenafpk@mail.ru
Russian Federation

Elena V. Loshkova

Siberian State Medical University

Email: loshkova@rambler.ru. loshkova.ev@ssmu.ru
Russian Federation

Natalya V. Kolesnikova

Kuban State Medical University

Email: troickaya@rambler.ru
Russian Federation

Anton V. Trembach

Kuban State Medical University; Children's Regional Clinical Hospital

Email: anton-trembach@yandex.ru
Russian Federation

Natalya V. Tarasenko

Siberian State Medical University; Institute of Medical Genetics

Email: nataly.tarasenko@medgenetics.ru
Russian Federation

Tatyana V. Asekretova

Kuban State Medical University; Children's Regional Clinical Hospital

Russian Federation

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Copyright (c) 2016 Kondrateva E.I., Loshkova E.V., Kolesnikova N.V., Trembach A.V., Tarasenko N.V., Asekretova T.V.

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This work is licensed under a Creative Commons Attribution 4.0 International License.