Osteopenia and osteoporosis after allogeneic hematopoietic stem cell transplantation, features of bone mineral turnover pathology in children

Among the numerous late effects of allogeneic hematopoietic stem cell transplantation (HSCT) the bone turnover pathology remains one of the frequent. Osteopenia and osteoporosis are multifactorial, progressive and long-term disturbances. They can lead to bone fractures and disability and significantly reduce the quality of life. In-time diagnostic of osteopenia and osteoporosis, appropriate and individualized therapeutic approach allow to improve the prognosis of patients. This article describes pathogenesis, diagnostic and recent treatment options of bone mineral pathology after allogeneic HSCT. Pecularities of these complications in children population are reviewed separately.