Email this article Echocardiographic assessment of the state of the heart in children with ß-thalassemia
- Authors: Nikolaeva G.N.1, Sugak A.B.1, Feoktistova E.V.1, Kurov I.O.2
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Affiliations:
- Dmitry Rogachev Federal Research Centre of Paediatric Haematology, Oncology and Immunology, Ministry of Health of the Russian Federation
- Moscow Institute of Physics and Technology (State University)
- Issue: Vol 15, No 3 (2016)
- Pages: 23-28
- Section: HEMATOLOGY
- Submitted: 19.09.2018
- Published: 19.09.2016
- URL: https://hemoncim.com/jour/article/view/166
- DOI: https://doi.org/10.24287/1726-1708-2016-15-3-23-28
- ID: 166
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Abstract
The main causes of the development of thalassemia-associated cardiomyopathy are volume overload of the heart resulting from adaptation to chronic anaemia and iron toxic effects on the myocardium resulting from replacement blood transfusion therapy. In order to reveal left ventricle (LV) dysfunction echocardiography (Echo-CG) with examination of the mitral valve fibrous ring (MV FR) motion was performed in the tissue Doppler mode in 50 patients with ß-thalassemia and 47 conditionally healthy children aged 2 to 16 years. Patients with ß-thalassemia as compared with the control group had a significantly larger LV diameter, higher LV volume indices, LV myocardial mass index, left atrial diameter, cardiac index, transmitral flow velocity, MV FR motion diastolic velocities and a ratio between LV early diastolic filling velocity and MV FR motion early diastolic velocity, significantly smaller LV ejection fraction (p < 0.5). LV wall thickness, LV myocardial mass, heart rate, LV stroke volume, LV minute volume, ratios between transmitral flow velocities, MV FR motion systolic velocities did not differ among groups. In patients with ß-thalassemia, echo-CG permits to diagnose dilatation, hypertrophy and hyperkinesis of LV associated with cardiac volume overload. The hyperkinetic status might mask early signs of diastolic dysfunction. For diagnosing early signs of systolic dysfunction it is necessary to develop reference values of LV ejection fraction for patients with ß-thalassemia.
About the authors
Galina N. Nikolaeva
Dmitry Rogachev Federal Research Centre of Paediatric Haematology, Oncology and Immunology, Ministry of Health of the Russian Federation
Author for correspondence.
Email: galina-2020@yandex.ru
Russian Federation
Anna B. Sugak
Dmitry Rogachev Federal Research Centre of Paediatric Haematology, Oncology and Immunology, Ministry of Health of the Russian Federation
Email: sugak08@mail.ru
Russian Federation
Elena V. Feoktistova
Dmitry Rogachev Federal Research Centre of Paediatric Haematology, Oncology and Immunology, Ministry of Health of the Russian Federation
Email: 9433672@mail.ru
Russian Federation
Il'ya O. Kurov
Moscow Institute of Physics and Technology (State University)
Email: kurov@phystech.edu
Russian Federation
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