Email this article Usage of heteropolysaccharides to restore the skin barrier function in patients with chronic "graft versus host" disease
- Authors: Rassokhina O.I.1, Trakhtman P.E.2, Potekaev N.N.1
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Affiliations:
- Russian National Research Medical University named after N.I. Pirogov
- Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology
- Issue: Vol 17, No 2 (2018)
- Pages: 76-83
- Section: ORIGINAL ARTICLES
- Submitted: 20.09.2018
- Published:
- URL: https://hemoncim.com/jour/article/view/178
- DOI: https://doi.org/10.24287/1726-1708-2018-17-2-76-83
- ID: 178
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Abstract
The article deals with the specific features of skin changes due to the chronical «graft-versus-host disease» (GVHD) reaction and practice of its drug-free modalities. This study involved 34 patients with skin manifestations of cGVHD, that were on the standard immunosuppressive therapy or extracorporeal photopheresis. The patients received non-invasive diagnostics of skin (high frequency ultrasound of skin, photodermatoscopy, sebumetry, corneometry), and also had their skin manifestations corrected with heteropolysaccharide. The outcome of the conducted study shows that rational topographical use of heteropolysaccharide on treatment of standard immunosuppressive therapy or extracorporeal photopheresis results in the recovery of epidermal barrier, bringing relief to personal discomfort as regressing the feeling of skin tightness and pruriency, fractional reduction of rash, which is confirmed by the data of the noninvasive methods of skin treatment. The noninvasive methods of valuating multifunctional skin health (high frequency ultrasound of skin, photodermatoscopy, sebumetry, corneometry) are applicable for case follow-up of patients with skin manifestations of сGVHD.
About the authors
O. I. Rassokhina
Russian National Research Medical University named after N.I. Pirogov
Author for correspondence.
Email: olga-shuginina@yandex.ru
ORCID iD: 0000-0002-2156-5487
assistant of the Department of Skin Diseases and Cosmetology
Russia 117997, Moscow, Ostrovitianov st., 1
Russian FederationP. E. Trakhtman
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology
ORCID iD: 0000-0002-0231-1617
Russian Federation
N. N. Potekaev
Russian National Research Medical University named after N.I. Pirogov
ORCID iD: 0000-0002-9331-7714
Russian Federation
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