Email this article Subsequent gliomas in survivors of paediatric neoplasms
- Authors: Shats L.I.1, Belogurova M.B.1, Ozerov S.S.2, Ektova A.P.2, Nechesnuk A.V.2, Rizhova M.V.3, Vizhlukova O.V.4, Doronina I.V.4, Tsirenova H.V.5, Grishina E.V.6, Zheludkova O.G.7, Rudneva A.E.2, Pshonkin A.V.8, Erega E.P.9, Kumirova E.V.10
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Affiliations:
- Division of Oncology, Saint-Petersburg State Paediatric Medical University St. Petersburg Clinical Research and Practical Center of Specialized Types of Medical Care (Oncologic)
- Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology
- N.N. Burdenko Neurosurgical Institute, Russian Academy of Medical Sciences
- Paediatric Hospital of Murmansk
- Buryatia Republican Oncology and Haematology Center, Ulan-Ude
- Children's Republican Clinical Hospital, Kazan
- Russian Scientific Center of Roentgenoradiology
- ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России
- Children's Regional Hospital, Khabarovsk
- Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology
- Issue: Vol 17, No 2 (2018)
- Pages: 84-91
- Section: ORIGINAL ARTICLES
- Submitted: 20.09.2018
- Published:
- URL: https://hemoncim.com/jour/article/view/179
- DOI: https://doi.org/10.24287/1726-1708-2018-17-2-84-91
- ID: 179
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Abstract
Multimodal therapy has improved survival for most childhood tumours. The development of neoplasms subsequent to therapeutic cranial irradiation is a rare but serious and potentially fatal complication. The analysis included 16 patients (pts.) with subsequent glioblastoma (SG) from several institutions in Russia who underwent cranial or neck irradiation (1 case) to treat their primary disease (acute lymphoblastic leukaemia – 12 pts., medulloblastoma – 2 pts., choroid plexus papilloma – 1 pts., lymphoma – 1 pts.). All gliomas arose within the previous radiation fields and satisfied the widely used criteria for the definition of radiation induced neoplasms. The median RT dose administered was 18 Gy with the dosage ranges being 12–55 Gy. TBI was used in one patient with Ph-positive ALL during bone marrow transplantation. Median latency period was 6 years until diagnosis of SG. The majority of SG (14 of 16) occurred during the initial 9 years of follow-up. Patients underwent surgery resection followed by standard fractionated local radiation and chemotherapy. A Kaplan–Meier analysis was used to illustrate the overall survival (OS) curves. OS rate was 34.4 ± 12.3% and 13,6 ± 9.0% at 1 and 2 years respectively with median 11 months. In case that paediatric neoplasms are treated by standard fractionated radiation or TBI is used, radiation-induced gliomas should be considered as possible long-term side effect. And the patients should be followed for a long term, even long after the period of risk for relapse of the primary cancer has passed.
Keywords
About the authors
L. I. Shats
Division of Oncology, Saint-Petersburg State Paediatric Medical UniversitySt. Petersburg Clinical Research and Practical Center of Specialized Types of Medical Care (Oncologic)
Author for correspondence.
Email: mila.shats@gmail.com
paediatric oncologist Division of Oncology, Paediatric Oncology and Radiotherapy, Division of Oncology
Russia 194353, St. Petersburg, Litovskaya str., 2
Tel.: +7 (921) 751-3882
M. B. Belogurova
Division of Oncology, Saint-Petersburg State Paediatric Medical UniversitySt. Petersburg Clinical Research and Practical Center of Specialized Types of Medical Care (Oncologic)
Russian Federation
S. S. Ozerov
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology,Immunology
Russian Federation
A. P. Ektova
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology,Immunology
Russian Federation
A. V. Nechesnuk
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology,Immunology
Russian Federation
M. V. Rizhova
N.N. Burdenko Neurosurgical Institute, Russian Academy of Medical SciencesRussian Federation
O. V. Vizhlukova
Paediatric Hospital of MurmanskRussian Federation
I. V. Doronina
Paediatric Hospital of MurmanskRussian Federation
H. V. Tsirenova
Buryatia Republican Oncology and Haematology Center, Ulan-UdeRussian Federation
E. V. Grishina
Children's Republican Clinical Hospital, KazanRussian Federation
O. G. Zheludkova
Russian Scientific Center of RoentgenoradiologyRussian Federation
A. E. Rudneva
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology,Immunology
Russian Federation
A. V. Pshonkin
ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава РоссииRussian Federation
E. P. Erega
Children's Regional Hospital, KhabarovskRussian Federation
E. V. Kumirova
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, ImmunologyRussian Federation
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