Ten years of experience of alendronate treatment of craniomaxillofacial fibrous dysplasia

Fibrous dysplasia is a benign rare hamartom disease of bones, characterized by a combination of fibrous tissue elements in the focis. At the present time surgical treatment is the most preferable, however, in the case of small foci or subtotal skull bone affected this approach is not rational or impossible. The accumulated foreign and our experience of conservative treatment of patients with bisphosphonate series increases the possibilities for choosing the tactics of treating patients with this congenital pathology. When using this drug, there was no development of serious adverse effects and in a number of cases, surgical treatment was avoided.