Email this article Development of total body irradiation method. From history to the present
- Authors: Loginova A.A.1, Nechesnyuk A.A.1, Kobyzeva D.A.1, Chernyaev A.P.2, Varzar S.M.2
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Affiliations:
- Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology
- Federal State Budget Educational Institution of Higher Education M.V. Lomonosov Moscow State University
- Issue: Vol 17, No 3 (2018)
- Pages: 133-139
- Section: LITERATURE REVIEW
- Submitted: 24.09.2018
- Accepted: 24.09.2018
- Published: 24.09.2018
- URL: https://hemoncim.com/jour/article/view/200
- DOI: https://doi.org/10.24287/1726-1708-2018-17-3-133-139
- ID: 200
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Abstract
This review provides information on total body irradiation (TBI), including the history of the development of the method, a brief description of the classical dose delivery methods, and the main difficulties of it's using. Recent years, TBI based on IMRT (Intensity Modulated Radiation Therapy) has been increasingly used. It is assumed that the toxicity of therapy decreases without an increasing of relapse probability. Using IMRT for TBI also allows to unify dose distribution within patients and, most importantly, provides us clear quantitative criteria necessary for assessing the clinical efficiency and toxicity of different regimens of therapy. Some radiobiological issues of TBI concerning the dose rate, skin irradiation necessity and the uniformity of circulating blood irradiation are also discussed.
About the authors
A. A. Loginova
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology
Author for correspondence.
Email: aloginovaa@gmail.com
ORCID iD: 0000-0002-6609-6071
Anna A. Loginova, Senior Medical Physicist in radiation therapy department
117997, Moscow, Samory Mashela st., 1
Russian FederationA. A. Nechesnyuk
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology
ORCID iD: 0000-0002-2537-6157
Russian Federation
D. A. Kobyzeva
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology
ORCID iD: 0000-0002-7743-8380
Russian Federation
A. P. Chernyaev
Federal State Budget Educational Institution of Higher Education M.V. Lomonosov Moscow State UniversityRussian Federation
S. M. Varzar
Federal State Budget Educational Institution of Higher Education M.V. Lomonosov Moscow State UniversityRussian Federation
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