Email this article Case report of the inflammatory myofibroblastic tumor of the liver in infant
- Authors: Suleymanova A.M.1, Filin A.V.2, Kachanov D.Y.1, Shamanskaya T.V.1, Metelin A.V.2, Feoktistova E.V.1, Roschin V.Y.1, Shcherbakov A.P.1, Tereschenko G.V.1, Zemcova L.V.1, Preobrazhenskaya E.V.3, Suspitsin E.N.3,4, Varfolomeeva S.R.1
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Affiliations:
- Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology
- B.V. Petrovsky Russian Scientific Center of Surgery
- N.N. Petrov National Medical Research Center of Oncology
- St. Petersburg State Pediatric Medical University
- Issue: Vol 17, No 3 (2018)
- Pages: 93-102
- Section: CLINICAL OBSERVATIONS
- Submitted: 24.09.2018
- Accepted: 24.09.2018
- Published: 24.09.2018
- URL: https://hemoncim.com/jour/article/view/202
- DOI: https://doi.org/10.24287/1726-1708-2018-17-3-93-102
- ID: 202
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Abstract
The inflammatory myofibroblastic tumor (IMT) is an extremely rare type of liver tumors in young children. This article presents a clinical case of the development of IMT of the liver in 11-month-old child with the detected chimeric TPM3ex6 / ALKex20 transcript. State-of-the-art data on the clinical presentation of IMT, histological and molecular genetic characteristics of the tumor, differential diagnosis of hepatic masses depending on the level of alpha-fetoprotein, the principles of treatment of IMT, based on a review of the scientific literature, including data on the effectiveness of ALK inhibitors are described.
About the authors
A. M. Suleymanova
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology
Author for correspondence.
Email: aminasuleymanova313@gmail.com
ORCID iD: 0000-0002-5489-1879
Amina M. Suleymanova, MD, рediatric oncologist, Department of сlinical оncology
117997, Moscow, Samory Mashela st., 1
Russian FederationA. V. Filin
B.V. Petrovsky Russian Scientific Center of SurgeryRussian Federation
D. Yu. Kachanov
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology
ORCID iD: 0000-0002-3704-8783
Russian Federation
T. V. Shamanskaya
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology
ORCID iD: 0000-0002-3767-4477
Russian Federation
A. V. Metelin
B.V. Petrovsky Russian Scientific Center of SurgeryRussian Federation
E. V. Feoktistova
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, ImmunologyRussian Federation
V. Yu. Roschin
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, ImmunologyRussian Federation
A. P. Shcherbakov
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, ImmunologyRussian Federation
G. V. Tereschenko
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology
ORCID iD: 0000-0001-7317-7104
Russian Federation
L. V. Zemcova
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, ImmunologyRussian Federation
E. V. Preobrazhenskaya
N.N. Petrov National Medical Research Center of OncologyRussian Federation
E. N. Suspitsin
N.N. Petrov National Medical Research Center of Oncology;St. Petersburg State Pediatric Medical University
ORCID iD: 0000-0001-9764-2090
Russian Federation
S. R. Varfolomeeva
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, ImmunologyRussian Federation
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