Email this article Brentuximab vedotin in the treatment of children and adolescents with refractory and relapsed Hodgkin's lymphoma
- Authors: Kozlov A.V.1, Kazantzev I.V.1, Iukhta T.V.1, Tolkunova P.S.1, Gevorgian A.G.1, Lepik K.V.1, Borzenkova E.S.1, Zaljalov Y.R.1, Botina A.V.1, Baikov V.V.1, Morozova E.V.1, Mikhailova N.B.1, Zubarovskaya L.S.1, Afanasyev B.V.1
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Affiliations:
- Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of Saint-Petersburg
- Issue: Vol 18, No 2 (2019)
- Pages: 83-91
- Section: ORIGINAL ARTICLES
- Submitted: 29.06.2019
- Accepted: 29.06.2019
- Published: 29.06.2019
- URL: https://hemoncim.com/jour/article/view/248
- DOI: https://doi.org/10.24287/1726-1708-2019-18-2-83-91
- ID: 248
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Abstract
Children and adolescents with refractory or relapsed Hodgkin's lymphoma (R-R HL) have unfavorable prognosis if ≥ 3 lines of therapies have to be used. New strategies based on innovative approaches are crucial for this group of patients. Nowadays immunotherapy for oncological diseases is the most promising and actively developing area. Brentuximab vedotin (BV) is efficient in adults with HL. Data in children are limited to pilot studies that are focused on response to treatment without analysis of survival. The present study demonstrates experience of Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation (First Pavlov State Medical University of Saint-Petersburg) in the management of heavily pretreated (median number of prior lines – 4) children and adolescents with R-R HL. The study was approved by the Independent Ethics Committee of the Raisa Gorbacheva Memorial Research Institute of Children's Oncology, Hematology and Transplantation. Brentuximab vedotin was administered to 34 patients. Overall response was achieved in 71% (complete response – 29%, partial response – 42%). Long-term progression free and overall survival were 24 and 54%, respectively.
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About the authors
A. V. Kozlov
Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of Saint-Petersburg
Author for correspondence.
Email: kozlovandrew@list.ru
ORCID iD: 0000-0003-4072-601X
Andrey V. Kozlov, senior researcher.
197022, Saint-Petersburg, Tolstoy st., 6/8.
Russian FederationI. V. Kazantzev
Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of Saint-Petersburg
ORCID iD: 0000-0002-3818-6213
Russian Federation
T. V. Iukhta
Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of Saint-Petersburg
ORCID iD: 0000-0002-5979-9182
Russian Federation
P. S. Tolkunova
Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of Saint-Petersburg
ORCID iD: 0000-0002-2296-0358
Russian Federation
A. G. Gevorgian
Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of Saint-Petersburg
ORCID iD: 0000-0003-2905-8209
Russian Federation
K. V. Lepik
Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of Saint-Petersburg
ORCID iD: 0000-0002-4056-050X
Russian Federation
E. S. Borzenkova
Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of Saint-Petersburg
ORCID iD: 0000-0003-1454-8045
Russian Federation
Yu. R. Zaljalov
Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of Saint-Petersburg
ORCID iD: 0000-0002-3881-4486
Russian Federation
A. V. Botina
Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of Saint-Petersburg
ORCID iD: 0000-0001-5991-0066
Russian Federation
V. V. Baikov
Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of Saint-Petersburg
ORCID iD: 0000-0002-9191-5091
Russian Federation
E. V. Morozova
Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of Saint-Petersburg
ORCID iD: 0000-0002-9605-485X
Russian Federation
N. B. Mikhailova
Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of Saint-Petersburg
ORCID iD: 0000-0002-2913-047X
Russian Federation
L. S. Zubarovskaya
Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of Saint-Petersburg
ORCID iD: 0000-0003-2594-7703
Russian Federation
B. V. Afanasyev
Raisa Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, First Pavlov State Medical University of Saint-Petersburg
ORCID iD: 0000-0002-1235-4530
Russian Federation
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