Email this article The phenomenon of conversion of the donor-derived blood group to the patient’s original blood group after ABO-incompatible hematopoietic stem cell transplantation in a patient with Wiskott–Aldrich syndrome
- Authors: Khoreva A.L.1, Trachtman P.E.1, Kozlovskaya S.N.1, Mitrakov K.V.1, Brilliantova V.V.1, Popov A.M.1, Balashov D.N.1
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Affiliations:
- Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation
- Issue: Vol 18, No 2 (2019)
- Pages: 103-107
- Section: CLINICAL OBSERVATIONS
- Submitted: 29.06.2019
- Accepted: 29.06.2019
- Published: 29.06.2019
- URL: https://hemoncim.com/jour/article/view/250
- DOI: https://doi.org/10.24287/1726-1708-2019-18-2-103-107
- ID: 250
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Abstract
We present a clinical case of hematopoietic stem cell transplantation (HSCT) in a patient with Wiskott-Aldrich syndrome. In spite of donor different ABO-system, the own blood group was verified in 6 months after HSCT, which was initially regarded as a risk of myeloid rejection. During the diagnosis, the hypothesis of absorption of the recipient’s ABO-system proteins onto the donorderived red blood cells was confirmed. The study of the immunological profile allowed to exclude the risks of hemolytic reactions and to predict a favorable outcome in the patient. Parents gave their consent to use information about the child in the article.
About the authors
A. L. Khoreva
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation
Author for correspondence.
Email: ania.tulip@mail.ru
ORCID iD: 0000-0002-7684-9188
Anna L. Khoreva, resident in pediatrics.
117997, Moscow, Samory Mashela st., 1.
Russian FederationP. E. Trachtman
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation
ORCID iD: 0000-0002-0231-1617
Russian Federation
S. N. Kozlovskaya
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation
ORCID iD: 0000-0002-1754-1220
Russian Federation
K. V. Mitrakov
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation
ORCID iD: 0000-0002-2010-5534
Russian Federation
V. V. Brilliantova
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian FederationRussian Federation
A. M. Popov
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation
ORCID iD: 0000-0002-0889-6986
Russian Federation
D. N. Balashov
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation
ORCID iD: 0000-0003-2689-0569
Russian Federation
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