Email this article Platelet functional activity: physiology and laboratory diagnostic methods
- Authors: Ponomarenko E.A.1,2, Ignatova A.A.1, Fedorova D.V.1, Zharkov P.A.1, Panteleev M.A.1,2,3,4
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Affiliations:
- Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation
- M.V. Lomonosov Moscow State University
- Center for Theoretical Problems of Physicochemical Pharmacology Russian Academy of Sciences
- Moscow Institute of Physics and Technology
- Issue: Vol 18, No 3 (2019)
- Pages: 112-119
- Section: LITERATURE REVIEW
- Submitted: 13.09.2019
- Accepted: 13.09.2019
- Published: 13.09.2019
- URL: https://hemoncim.com/jour/article/view/268
- DOI: https://doi.org/10.24287/1726-1708-2019-18-3-112-119
- ID: 268
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Abstract
Platelets perform numerous important functions not only in the process of normal functioning of hemostatic system, but also in other physiological processes, such as: vessel wall integrity regulation, wound healing, inflammatory response. Its malfunction can be found in various diseases and conditions (including oncohematological disorders, solid tumors, inflammatory diseases, sepsis, autoimmune disorders), is triggered by injury or medications and can lead to dangerous consequences, such as bleeding and thrombosis. However, platelets functional activity quantity assessment tools are extremely limited, the perception what platelet functional activity is about is also quite unclear. This review considers platelets function, its' abnormalities, possibilities for its' assessment by existing methods as well as promising directions for their development.
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About the authors
E. A. Ponomarenko
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation;M.V. Lomonosov Moscow State University
Author for correspondence.
Email: pappe@bk.ru
ORCID iD: 0000-0002-8697-7570
Evgeniya A. Ponomarenko, Junior research fellow of laboratory of cellular hemostasis and thrombosis, Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation
117997, Moscow, Samory Mashela st., 1
Russian FederationA. A. Ignatova
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation
ORCID iD: 0000-0002-5217-3937
Moscow Russian Federation
D. V. Fedorova
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation
ORCID iD: 0000-0003-4567-1871
Moscow Russian Federation
P. A. Zharkov
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation
ORCID iD: 0000-0003-4384-6754
Moscow Russian Federation
M. A. Panteleev
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation;M.V. Lomonosov Moscow State University;
Center for Theoretical Problems of Physicochemical Pharmacology Russian Academy of Sciences;
Moscow Institute of Physics and Technology
ORCID iD: 0000-0002-8128-7757
Moscow Russian Federation
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