Hyperleucocytosis in children with acute mieloid leukemia

N. V. Zacharov; Захаров Н. В.; I. I. Kalinina; Калинина И. И.; D. A. Venev; Венёв Д. А.; T. Y. Salimova; Салимова Т. Ю.; D. A. Evseev; Евсеев Д. А.; O. V. Goronkova; Горонкова О. В.; A. A. Maschan; Масчан А. А.

doi:10.24287/1726-1708-2020-19-1-116-121

Hyperleucocytosis in children with acute mieloid leukemia

Authors: Zacharov N.V.¹, Kalinina I.I.², Venev D.A.², Salimova T.Y.², Evseev D.A.², Goronkova O.V.², Maschan A.A.²
Affiliations:
1. Krasnoyarsk Clinical Center of maternity and childhood
2. Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation
Issue: Vol 19, No 1 (2020)
Pages: 116-121
Section: LITERATURE REVIEW
Submitted: 28.03.2020
Accepted: 28.03.2020
Published: 28.03.2020
URL: https://hemoncim.com/jour/article/view/314
DOI: https://doi.org/10.24287/1726-1708-2020-19-1-116-121
ID: 314

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Abstract

This article presents analysis of recent publications on hyperleukocytosis in children with AML. The mechanisms of the development of life-threatening complications accompanying hyperleukocytosis are analyzed in detail. In this review of the literature, the authors focus on the adequacy and timing of therapy for such life-threatening complications of hyperleukocytosis as leukostasis, DIC, and acute tumor lysis syndrome. The authors emphasize that in the treatment of hyperleukocytosis an important place, in addition to specific therapy, is taken by the accompanying therapy in the intensive care unit. The place of replacement blood transfusions and leukopheresis as part of the accompanying therapy is discussed.

Keywords

children, acute myeloid leukemia, chemotherapy

About the authors

N. V. Zacharov

Krasnoyarsk Clinical Center of maternity and childhood

Krasnoyarsk Russian Federation

I. I. Kalinina

Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation

Author for correspondence.
Email: irina.kalinina@fccho-moscow.ru
ORCID iD: 0000-0002-0813-5626

MD, Pediatrician Hematologist, Department of Pediatric Hematology/Oncology,

117997, Moscow, Samory Mashela st., 1

Russian Federation

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