Combined disorder of procoagulant activity and platelet secretion with normal aggregation in a patient with a bleeding tendency

D. M. Polokhov; Полохов Д.М.; S. A. Vasiliev; Васильев С.А.; N. I. Zozulya; Зозуля Н.И.; M. A. Kumskova; Кумскова М.А.; T. N. Moiseeva; Моисеева Т.Н.; L. S. Al-Radi; Аль-Ради Л.С.; M. A. Panteleev; Пантелеев М.А.

doi:10.24287/1726-1708-2018-17-1-93-96

Combined disorder of procoagulant activity and platelet secretion with normal aggregation in a patient with a bleeding tendency

Authors: Polokhov D.M.¹, Vasiliev S.A.², Zozulya N.I.², Kumskova M.A.², Moiseeva T.N.², Al-Radi L.S.², Panteleev M.A.³
Affiliations:
1. Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology
2. National Medical Research Center of Hematology
3. Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Center for Theoretical Problems of Physico-Chemical Pharmacology Lomonosov Moscow State University Moscow Institute of Physics and Technology (State University)
Issue: Vol 17, No 1 (2018)
Pages: 93-96
Section: Статьи
Submitted: 09.08.2018
Published: 09.02.2018
URL: https://hemoncim.com/jour/article/view/32
DOI: https://doi.org/10.24287/1726-1708-2018-17-1-93-96
ID: 32

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Abstract

A 54-year-old woman with a bleeding tendency after surgical interventions revealed abnormalities in the functional activity of platelets in the form of decreased phosphatidylserine exposure and the release of dense and α-granules. The morphology of the platelets remained normal, as was the aggregation function in the Born-O'Brien method with activation of ADP, collagen and ristomycin. In the study of plasma hemostasis, there were no abnormalities. The findings indicate that the patient has an unclassified thrombocytopathy.

Keywords

bleeding tendency, dysfunction of platelets, flow cytometry, aggregation of platelets, platelet functional activity

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