The treatment of multiple organ dysfunction syndrome caused by gram-negative sepsis in a patient with neutropenia after allogeneic hematopoietic stem cell transplantation: a case report

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Abstract

Patients with high-dose chemotherapy-induced immunosuppression are at high risk for infectious complications with multiple organ dysfunction, which may lead to significantly higher mortality. We report a clinical case of multiple organ dysfunction syndrome caused by gram-negative septic shock in a child after allogeneic hematopoietic stem cell transplantation. We describe intensive care treatment modalities employed at different stages of therapy as well as the specifics of vital signs monitoring. The patient's parents gave their consent to the use of their child's data, including photographs, for research purposes and in publications.

About the authors

A. Yu. Ivanashkin

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation

Author for correspondence.
Email: ivanashkin@yandex.ru
ORCID iD: 0000-0002-4348-4573

Anesthesiologist-Intensivist at the Intensive Care Unit,

Russia, 117997, Moscow, Samory Mashela st., 1

Russian Federation

V. V. Lazarev

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation; N.I. Pirogov Russian National Research Medical University of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0001-8417-3555
Russian Federation

I. G. Khamin

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0001-8264-2258
Russian Federation

I. A. Semenov

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0002-4695-9765
Russian Federation

L. N. Shelikhova

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0003-0520-5630
Russian Federation

A. A. Maschan

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0002-0016-6698
Russian Federation

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Copyright (c) 2020 Ivanashkin A.Y., Lazarev V.V., Khamin I.G., Semenov I.A., Shelikhova L.N., Maschan A.A.

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