Email this article Application of flow systems in laboratory diagnostics for the integral evaluation of the hemostatic system
- Authors: Ushakova O.E.1, Nechipurenko D.Y.2, Butylin A.A.3, Panteleev M.A.4
-
Affiliations:
- I.M. Sechenov First Moscow State Medical University (Sechenov University) Center for Theoretical Problems of Physicochemical Pharmacology Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology
- Center for Theoretical Problems of Physicochemical Pharmacology Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Faculty of Physics, Moscow State University
- Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Faculty of Physics, Moscow State University
- Center for Theoretical Problems of Physicochemical Pharmacology Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Faculty of Physics, Moscow State University Moscow Institute of Physics and Technology (State University)
- Issue: Vol 17, No 1 (2018)
- Pages: 117-132
- Section: Статьи
- Submitted: 09.08.2018
- Published: 09.02.2018
- URL: https://hemoncim.com/jour/article/view/37
- DOI: https://doi.org/10.24287/1726-1708-2018-17-1-117-132
- ID: 37
Cite item
Full Text
Abstract
The assessment of thrombosis and bleeding risks is one of the most important tasks of laboratory diagnostics of disorders in the hemostasis system. For this purpose the highly specialized tests are not always appropriate, because these assays are focused on specific markers or pathologies of individual links: the level of coagulation factors, the level of D-dimers, ADP- and serotonininduced platelet activation, effects of acetyl salicylic acid on aggregation. Nowadays, integral assays are the most promising approach, simulating hemostatic process in vivo – thromboelastography, thrombodynamics, thrombin generation. These tests are designed to specify the risk of thrombosis or bleeding with co-origin, as well as screening and monitoring of drug therapy. One of the approaches in the development of integral assays are flow systems where plasma or whole blood flow is formed over the hemostatic activator, and the growth of the thrombus is recorded on the video. There are commercially available samples of such devices, and some experience of its application in clinic. However, there are no uniform standards and clinical guidelines. This review describes examples of flow chambers exploitation for diagnosis, existing problems of its usage and the opportunities that it can provide to the clinicians.
About the authors
O. E. Ushakova
I.M. Sechenov First Moscow State Medical University (Sechenov University)Center for Theoretical Problems of Physicochemical Pharmacology
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology
Author for correspondence.
Russian Federation
D. Y. Nechipurenko
Center for Theoretical Problems of Physicochemical PharmacologyDmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology
Faculty of Physics, Moscow State University
Russian Federation
A. A. Butylin
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, ImmunologyFaculty of Physics, Moscow State University
Russian Federation
M. A. Panteleev
Center for Theoretical Problems of Physicochemical PharmacologyDmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology
Faculty of Physics, Moscow State University
Moscow Institute of Physics and Technology (State University)
Email: mapanteleev@yandex.ru
ORCID iD: 0000-0002-8128-7757
PhD, DSc, Head of the Laboratory of cellular hemostasis and trombosis
Russia 117997, Moscow, Samory Mashela st., 1
Russian FederationReferences
Supplementary files
