Therapy-related acute myeloid leukemia in a patient with neuroblastoma: case report

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Abstract

Modern, risk-adapted treatment approaches for intermediate and high-risk neuroblastoma (NB) have led to an increasing numbers of survivors. However, intensive multimodal treatment strategy is associated with a significantly increased risk of secondary malignancies. It is currently known that alkylating agents, topoisomerase II inhibitors, and platinum compounds induce treatment-related leukemia. This article presents a literature review and description of a clinical case of secondary acute myeloid leukemia (s-AML) developed 57 months after the initial diagnosis in a patient with intermediate-risk NB who received intensive first-line and post-relapse chemotherapy. The debut of s-AML required a differential diagnosis to rule out a relapse of NB. Parents gave their consent to use information about the child, including fotos, in the article.

About the authors

D. T. Utalieva

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Healthcare of Russian Federation,

Author for correspondence.
Email: clinoncology@gmail.com
ORCID iD: 0000-0001-7479-0007

Physician of Department of Сlinical Оncology, 

117997, Moscow, Samory Mashela st., 1

Russian Federation

I. I. Kalinina

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Healthcare of Russian Federation,

ORCID iD: 0000-0002-0813-5626
117997, Moscow, Samory Mashela st., 1 Russian Federation

D. Yu. Kachanov

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Healthcare of Russian Federation,

ORCID iD: 0000-0002-3704-8783
117997, Moscow, Samory Mashela st., 1 Russian Federation

D. A. Evseev

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Healthcare of Russian Federation,

ORCID iD: 0000-0001-8610-0624
117997, Moscow, Samory Mashela st., 1 Russian Federation

A. P. Shcherbakov

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Healthcare of Russian Federation,

ORCID iD: 0000-0001-8129-0545
117997, Moscow, Samory Mashela st., 1 Russian Federation

M. Ye. Dubrowina

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Healthcare of Russian Federation,

117997, Moscow, Samory Mashela st., 1 Russian Federation

R. A. Moiseenko

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Healthcare of Russian Federation,

ORCID iD: 0000-0002-9654-084X
117997, Moscow, Samory Mashela st., 1 Russian Federation

Yu. N. Likar

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Healthcare of Russian Federation,

ORCID iD: 0000-0002-6158-2222
117997, Moscow, Samory Mashela st., 1 Russian Federation

T. V. Shamanskaya

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Healthcare of Russian Federation,

ORCID iD: 0000-0002-3767-4477
117997, Moscow, Samory Mashela st., 1 Russian Federation

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Copyright (c) 2025 Utalieva D.T., Kalinina I.I., Kachanov D.Y., Evseev D.A., Shcherbakov A.P., Dubrowina M.Y., Moiseenko R.A., Likar Y.N., Shamanskaya T.V.

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