Noninvasive assessment of iron overload by magnetic resonance imaging

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Abstract

The assessment of iron accumulation in the body is important for the diagnosis of iron overload syndrome or planning and monitoring of the chelation therapy. Excessive iron accumulation in the organs leads to their toxic damage and dysfunction. Until recently iron estimation was performed either directly by liver iron concentration and/or indirectly by measuring of serum ferritin level. However, noninvasive iron assessment by Magnetic resonance imaging (MRI) is more accurate method unlike liver biopsy or serum ferritin level test. In this article, we demonstrate the outlines of non-invasive diagnostics of iron accumulation by MRI and its specifications.

About the authors

E. E. Nazarova

Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology Ministry of Healthcare Russian Federation

Author for correspondence.
Email: evelina.nazarova@fccho-moscow.ru
ORCID iD: 0000-0002-0014-9345

research assistant, radiologist of radiology department, 

117997, Moscow, Samory Mashela st., 1

Russian Federation

D. A. Kupriyanov

Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology Ministry of Healthcare Russian Federation;
Philips “Healthcare”

ORCID iD: 0000-0002-5662-896X
117997, Moscow, Samory Mashela st., 1 Russian Federation

G. A. Novichkova

Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology Ministry of Healthcare Russian Federation

ORCID iD: 0000-0002-2322-5734
117997, Moscow, Samory Mashela st., 1 Russian Federation

G. V. Tereshchenko

Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology Ministry of Healthcare Russian Federation

ORCID iD: 0000-0001-7317-7104
117997, Moscow, Samory Mashela st., 1 Russian Federation

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Copyright (c) 2025 Nazarova E.E., Kupriyanov D.A., Novichkova G.A., Tereshchenko G.V.

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