Email this article Challenges in the diagnosis of growing teratoma syndrome: two case reports
- Authors: Sinichenkova K.Y.1, Tyutikova E.S.1, Likar Y.N.1, Mitrofanova A.M.1, Konovalov D.M.1, Litvinov D.V.1, Zhukov N.V.1
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Affiliations:
- Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
- Issue: Vol 19, No 4 (2020)
- Pages: 126-132
- Section: CLINICAL OBSERVATIONS
- Submitted: 21.12.2020
- Accepted: 21.12.2020
- Published: 08.07.2025
- URL: https://hemoncim.com/jour/article/view/428
- DOI: https://doi.org/10.24287/1726-1708-2020-19-4-126-132
- ID: 428
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Abstract
Growing teratoma syndrome (GTS) is reported to have an incidence of 1.9–7.6% among all germ cell tumours (GCT) and is often mistaken for tumor progression. There are no absolute signs or symptoms of GTS but it can be suspected based on the following criteria: the normalization of tumour markers, the enlargement of the mass and the presence in the tumour of mature teratoma cells alone. A delayed tumor resection in GTS can result in higher surgical risks and/or the infeasibility of complete resection. In 72–83% of cases, incomplete resection leads to relapses in the form of mature teratoma growth. A repeat biopsy is recommended in all patients with suspected GTS so that to avoid chemotherapy that would be ineffective in this disease. The article reports two clinical cases of GTS illustrating challenges inherent in the diagnosis of this syndrome. In each case, the parents gave consent to the use of their child's data, including photographs, for research purposes and in publications.
About the authors
K. Yu. Sinichenkova
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
Author for correspondence.
Email: sinich-aksiniya@mail.ru
ORCID iD: 0000-0002-1661-4205
Ksenia Yu. Sinichenkova, pediatric oncologist at the Department of Adolescent Hematology/Oncology and Neuro-oncology
1 Samory Mashela St., Moscow 117997
Russian FederationE. S. Tyutikova
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian FederationMoscow Russian Federation
Yu. N. Likar
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0002-6158-2222
Moscow Russian Federation
A. M. Mitrofanova
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0003-0368-2708
Moscow Russian Federation
D. M. Konovalov
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0003-2062-6740
Moscow Russian Federation
D. V. Litvinov
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0002-7461-0050
Moscow Russian Federation
N. V. Zhukov
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0002-9054-5068
Moscow Russian Federation
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