Chronic nonbacterial osteomyelitis: single center experience

A. L. Kozlova; Козлова А. Л.; V. I. Burlakov; Бурлаков В. И.; Z. A. Nesterenko; Нестеренко З. А.; N. V. Kuzmenko; Кузьменко Н. Б.; E. A. Deordieva; Деордиева Е. А.; A. A. Рoppelt; Роппельт А. А.; N. Yu. Kan; Кан Н. Ю.; O. A. Shvets; Швец О. А.; A. A. Moiseeva; Моисеева А. А.; S. A. Dibirova; Дибирова С. А.; A. L. Horeva; Хорева А. Л.; Yu. A. Rodina; Мухина А. А.; A. A. Muchina; Родина Ю. А.; N. A. Bolshakov; Большаков Н. А.; A. P. Shcherbakov; Щербаков А. П.; A. N. Remizov; Ремизов А. Н.; G. V. Tereshchenko; Терещенко Г. В.; V. Yu. Roshchin; Рощин В. Ю.; D. M. Konovalov; Коновалов Д. М.; Yu. N. Likar; Ликарь Ю. Н.; A. Yu. Shcherbina; Щербина А. Ю.

doi:10.24287/1726-1708-2020-19-4suppl-76-84

Chronic nonbacterial osteomyelitis: single center experience

Authors: Kozlova A.L.¹, Burlakov V.I.¹, Nesterenko Z.A.¹, Kuzmenko N.V.¹, Deordieva E.A.¹, Рoppelt A.A.¹, Kan N.Y.¹, Shvets O.A.¹, Moiseeva A.A.¹, Dibirova S.A.¹, Horeva A.L.¹, Rodina Y.A.¹, Muchina A.A.¹, Bolshakov N.A.¹, Shcherbakov A.P.¹, Remizov A.N.¹, Tereshchenko G.V.¹, Roshchin V.Y.¹, Konovalov D.M.¹, Likar Y.N.¹, Shcherbina A.Y.¹
Affiliations:
1. Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Healthcare of the Russian Federation
Issue: Vol 19, No 4 (2020): supplement
Pages: 76-84
Section: MATERIALS OF THE 3rd WORKING MEETING OF ALLERGISTS-IMMUNOLOGISTS
Submitted: 09.01.2021
Accepted: 09.01.2021
Published: 09.01.2021
URL: https://hemoncim.com/jour/article/view/449
DOI: https://doi.org/10.24287/1726-1708-2020-19-4suppl-76-84
ID: 449

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Abstract

Chronic nonbacterial osteomyelitis (CNO) is a rare autoinflammatory disease from the group of multifactorial diseases. It is characterized by non-infectious recurrent bone lesions, usually manifesting in childhood. The aim of this study was to analyze the clinical, laboratory, radiological and histological data of 33 patients (12 boys, 21 girls) with a diagnosis of chronic nonbacterial osteomyelitis. This study is supported by the Independent Ethics Committee and approved by the Academic Council of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology. 25/33 patients were hospitalized to the Center with suspected neoplastic disease bone. The median age of CNO manifestation was 9.6 years. 24/33 had a multi-focal form of the disease. 5 patients had fever. Nonsteroidal anti-inflammatory drugs were the first therapy for all patients, achieving clinical remission in 4 cases. Zoledronic acid were used in 29 patients with remission in 19, adalimumab in 10 patient with remission in 9. In one patient stabilization was achieved only with the combination of methotrexate and canakinumab therapy.

Keywords

autoinflammatory syndromes, chronic nonbacterial osteomyelitis, chronic recurrent multifocal osteomyelitis, bisphosphonates, tumor necrosis factor alpha inhibitors, children

About the authors

A. L. Kozlova

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Healthcare of the Russian Federation

Author for correspondence.
Email: annamax-99@mail.ru
ORCID iD: 0000-0002-2869-6535

Cand. Med. Sci., a senior researcher at the Department of Treatment Optimization for Immunodeficiencies, Department of Immunology

1 Samory Mashela St., Moscow 117997, Russia

Russian Federation

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