Granulomatous skin lesion as a manifestation of primary immunodeficiency in children

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Abstract

Primary immunodeficiencies (PID) compile a genetically heterogeneous group of more than 400 disorders. Most patients with PID are shown to be highly susceptible to various types of infectious diseases. However, in the past decade, non-infectious complications associated with immune dysregulation and autoimmunity have been increasingly recognized in PID. Patients with PID often have skin manifestations, that allow to suspect the diagnosis of immunodeficiency in early childhood. One of the least studied skin manifestations of PID is granulomatous dermatitis. This manuscript current research on the pathogenesis, methods of diagnosis and therapy of granulomatous dermatitis in patients with various PID.

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O. S. Selezneva

Regional children's clinical hospital

Author for correspondence.
Email: Selezneva-doc@mail.ru
ORCID iD: 0000-0003-1907-4168
allergist-immunologist of the department of pediatric hematology and oncology with chemotherapy

339
th Strelkovoy Divisii St. 14, Rostov-on-Don 344014, Russia

Russian Federation

A. Yu. Shcherbina

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0002-3113-4939
Moscow

Russian Federation

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Copyright (c) 2021 Selezneva O.S., Shcherbina A.Y.

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