Email this article Analysis of platelet RNA: a non-invasive method for studying the expression of tumor genes
- Authors: Tesakov I.P.1, Martyanov A.A.2,3, Drui A.E.2, Sveshnikova A.N.2,3
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Affiliations:
- Lomonosov Moscow State University
- Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Healthcare of the Russian Federation
- Center for Theoretical Problems of Physicochemical Pharmacology, RAS
- Issue: Vol 20, No 1 (2021)
- Pages: 207-217
- Section: LITERATURE REVIEW
- Submitted: 21.04.2021
- Accepted: 21.04.2021
- Published: 21.04.2021
- URL: https://hemoncim.com/jour/article/view/499
- DOI: https://doi.org/10.24287/1726-1708-2021-20-1-207-217
- ID: 499
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Abstract
Nowadays much attention is paid to non-invasive methods of cancer diagnostics and monitoring. One of the promising methods is the sequencing of platelet RNA (tumor-educated platelets), in which, as it was previously established, the mRNA repertoire changes in various oncological diseases. Thus, platelets can contain information about the molecular genetic characteristics of tumor. This review summarizes the current understanding of the mechanisms of interaction between tumor cells and platelets, and also discusses the possibilities of using platelet transcriptome analysis methods for diagnosing and assessing the dynamics of the tumor state, in particular, in response to therapy, as well as the current limitations for a wide range of introduction of this method into clinical practice.
About the authors
I. P. Tesakov
Lomonosov Moscow State University
ORCID iD: 0000-0002-9366-3449
Moscow
Russian FederationA. A. Martyanov
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Healthcare of the Russian Federation;Center for Theoretical Problems of Physicochemical Pharmacology, RAS
ORCID iD: 0000-0003-0211-6325
Moscow
Russian FederationA. E. Drui
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0003-1308-8622
Moscow
Russian FederationA. N. Sveshnikova
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Healthcare of the Russian Federation;Center for Theoretical Problems of Physicochemical Pharmacology, RAS
Author for correspondence.
Email: a.sveshnikova@physics.msu.ru
ORCID iD: 0000-0003-4720-7319
head of the Intracellular signalling and systems biology laboratory,
30 Srednyaya Kalitnikovskaya st., 109029 Moscow
Russian FederationReferences
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