Application of high-performance liquid chromatography in porphyrias diagnostics

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Abstract

Porphyrias are distinguished by the stage of heme synthesis at which a failure occurs, leading to the accumulation of intermediate products – porphyrins. Due to the low specificity of clinical manifestations of porphyria and the latent course of the disease, their timely diagnosis is difficult. This article substantiates the effectiveness of high-performance liquid chromatography method in the determination of porphyrins. The method is suitable for porphyrin determination in urine, blood and feces of patients. Examples of its work are shown.

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А. I. Puzikova

I.M. Sechenov First Moscow State Medical University of Ministry of Healthcare of the Russian Federation

Author for correspondence.
Email: puzikova_a_i@student.sechenov.ru
ORCID iD: 0000-0001-7848-8112

Alexandra I. Puzikova, Student

8-2 Trubetskaya St., Moscow 119991 

Russian Federation

Е. А. Litvin

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0002-6331-5339

Moscow

Russian Federation

D. А. Kildyushkin

I.M. Sechenov First Moscow State Medical University of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0001-8807-2145

Moscow

Russian Federation

А. Е. Druy

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0003-1308-8622

Moscow

Russian Federation

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Copyright (c) 2021 Puzikova А.I., Litvin Е.А., Kildyushkin D.А., Druy А.Е.

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