Email this article To a question of personalisation opportunities of application of chemotherapy brain tumors on the example of a temozolomid
- Authors: Shcherbenko O.I.1, Kumirova E.V.2
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Affiliations:
- The Russian Research Centre of Roentgenradiology
- National Scientific and Practical Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev
- Issue: Vol 16, No 2 (2017)
- Pages: 84-90
- Section: Статьи
- Submitted: 10.08.2018
- Published: 10.06.2017
- URL: https://hemoncim.com/jour/article/view/60
- DOI: https://doi.org/10.24287/1726-1708-2017-16-2-84-90
- ID: 60
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Abstract
Widespread introduction in the protocols of treatment of patients with tumors of a CNS of a chemotherapy allowed to improve the prognosis for many patients. At the same time, for a part of patients use of an chemotherapy does not give desirable effect, significantly increases treatment cost, and followed by toxic complications. On the example of use of a temozolomide in treatment of gliomas it is shown that its application allows to improve results of treatment only at a part of patients with the concrete positive clinico-biological and molecular characteristics. For the others patients medicine does not give positive results and significantly increases treatment cost. Experience of application of a temozolomid demonstrates that it is possible to personalize programs of treatment on the basis of already established prognostic factors. Their use will allow to refuse reference application of drugs according to only morphologic or only clinicoradiological diagnostics and to be guided by the individualized indications based on the clinico-biological parameters and molecular characteristics of this tumor. It will allow to reduce treatment cost at preservation of its effectiveness and decrease of toxic complications.
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About the authors
O. I. Shcherbenko
The Russian Research Centre of Roentgenradiology
Author for correspondence.
Email: sherbenko@mail.ru
ORCID iD: 0000-0003-0786-5448
MD, DSc, Professor, Head of Scientific-organizational Department
Russia 117997, Moscow, 86 Profsoyuznaya street
+7 (916) 573-4272
Russian FederationE. V. Kumirova
National Scientific and Practical Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev
ORCID iD: 0000-0001-6125-2410
Russian Federation
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