The results of pilot trial ALL-REZ-MВ-2014 for children with relapsed acute lymphoblastic leukemia

Yu. Yu. Dyakonova; Дьяконова Ю. Ю.; O. I. Bydanov; Быданов О. И.; N. V. Myakova; Мякова Н. В.; Yu. G. Abugova; Абугова Ю. Г.; O. V. Aleynikova; Алейникова О. В.; O. R. Arakayev; Аракаев О. Р.; E. G. Boychenko; Бойченко Э. Г.; M. E. Dubrovina; Дубровина М. Э.; D. A. Yevstratov; Евстратов Д. А.; D. V. Litvinov; Литвинов Д. В.; Yu. V. Olshanskaya; Ольшанская Ю. В.; N. I. Ponomareva; Пономарева Н. И.; A. M. Popov; Попов А. М.; L. A. Potapenko; Потапенко Л. А.; A. V. Rogov; Рогов А. В.; Yu. V. Rumyantseva; Румянцева Ю. В.; V. V. Fominykh; Фоминых В. В.; L. A. Khachatryan; Хачатрян Л. А.; A. I. Karachunsky; Карачунский А. И.

doi:10.24287/1726-1708-2017-16-3-7-14

The results of pilot trial ALL-REZ-MВ-2014 for children with relapsed acute lymphoblastic leukemia

Authors: Dyakonova Y.Y.¹, Bydanov O.I.², Myakova N.V.¹, Abugova Y.G.¹, Aleynikova O.V.³, Arakayev O.R.⁴, Boychenko E.G.⁵, Dubrovina M.E.¹, Yevstratov D.A.¹, Litvinov D.V.¹, Olshanskaya Y.V.¹, Ponomareva N.I.⁶, Popov A.M.¹, Potapenko L.A.¹, Rogov A.V.⁷, Rumyantseva Y.V.¹, Fominykh V.V.¹, Khachatryan L.A.¹, Karachunsky A.I.¹
Affiliations:
1. Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation
2. Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation Republican Research Center for Pediatric Oncology, Hematology and Immunology
3. Republican Research Center for Pediatric Oncology, Hematology and Immunology
4. Regional Children's Hospital № 1
5. 1 Children's hospital
6. Russian Children's Clinical Hospital
7. Pediatric oncology and hematology of the Reginal Children's Hospital
Issue: Vol 16, No 3 (2017)
Pages: 7-14
Section: Статьи
Submitted: 10.08.2018
Published: 10.08.2017
URL: https://hemoncim.com/jour/article/view/62
DOI: https://doi.org/10.24287/1726-1708-2017-16-3-7-14
ID: 62

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Abstract

The relapse of acute lymphoblastic leukemia (ALL) in children is still a difficult task. This is due both to the difficulties of achieving a second remission and to the problems of organizing allogeneic bone marrow transplantation (BMT) in those patients who need it. The standard approach is the use of second-line drugs in the regime of high-dosage chemotherapy blocks, but the response rate for this treatment in patients with early relapses remains low and the response time is short. Recently, new drugs with different mechanisms of action have appeared that can give an opportunity for a full remission. The organization of a multicentre study on anti-relapse therapy in the Russian Federation is an urgent task, the solution of which can help in studying new approaches to therapy and in the organization of BMT logistics. This article presents the results of a pilot multicentre study on the treatment of relapses of ALL in children in the Russian Federation. The effectiveness of standard therapy for a group with late relapses and the efficacy and toxicity of interventional blocks with the use of bortezomib, clofarabine, nelarabine are presented.

Keywords

acute lymphoblastic leukemia, relapse, children

About the authors

Yu. Yu. Dyakonova

Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation

Author for correspondence.
Email: Yuliya.Dyakonova@fcchomoscow.ru
ORCID iD: 0000-0002-8725-7532

MD, hematologist. Department of information technologies’ development

Russia 117997, Moscow, Samory Mashela st., 1

Russian Federation

O. I. Bydanov

Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation

Republican Research Center for Pediatric Oncology, Hematology and Immunology

Moscow

Minsk, Republic of Belarus

Russian Federation

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