The use of adoptive cell therapy for the treatment of SARS-CoV-2 in a patient after allogeneic hematopoietic stem cell transplantation

M. E. Leontyeva; Леонтьева М. Е.; E. R. Sultanova; Султанова Э. Р.; S. A. Radygina; Радыгина С. А.; Yu. V. Skvortsova; Скворцова Ю. В.; Ya. O. Muzalevskiy; Музалевский Я. О.; E. E. Kurnikova; Курникова Е. Е.; D. E. Pershin; Першин Д. Е.; M. A. Maschan; Масчан М. А.; D. N. Balashov; Балашов Д. Н.

doi:10.24287/1726-1708-2022-21-2-112-117

The use of adoptive cell therapy for the treatment of SARS-CoV-2 in a patient after allogeneic hematopoietic stem cell transplantation

Authors: Leontyeva M.E.¹, Sultanova E.R.¹, Radygina S.A.¹, Skvortsova Y.V.¹, Muzalevskiy Y.O.¹, Kurnikova E.E.¹, Pershin D.E.¹, Maschan M.A.¹, Balashov D.N.¹
Affiliations:
1. Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
Issue: Vol 21, No 2 (2022)
Pages: 112-117
Section: CLINICAL OBSERVATIONS
Submitted: 24.06.2022
Accepted: 24.06.2022
Published: 08.07.2025
URL: https://hemoncim.com/jour/article/view/623
DOI: https://doi.org/10.24287/1726-1708-2022-21-2-112-117
ID: 623

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Abstract

The COVID-19 pandemic continues to be a major public health threat worldwide. The course of this disease in immunocompromised patients is significantly different from that in healthy subjects, which is associated with the impossibility of virus elimination through their own adaptive immune response. Delayed immune reconstitution after hematopoietic stem cell transplantation (which may take months after the procedure) increases the risk of life-threatening COVID-19 infection necessitating a search for and application of new methods of treatment. T lymphocytes are critically important for viral infection control, and are necessary both for the direct elimination of Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation. The patient's parents gave consent to the use of their child's data, including photographs, for research purposes and in publications.