Email this article The role of gangliosides in the modulation of carcinogenesis
- Authors: Ivanov N.S.1, Kholodenko R.V.2, Kachanov D.Y.1, Larin S.S.1, Mollaev M.D.1, Shamanskaya T.V.1
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Affiliations:
- Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
- M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
- Issue: Vol 21, No 2 (2022)
- Pages: 157-166
- Section: LITERATURE REVIEW
- Submitted: 26.06.2022
- Accepted: 26.06.2022
- Published: 08.07.2025
- URL: https://hemoncim.com/jour/article/view/628
- DOI: https://doi.org/10.24287/1726-1708-2022-21-2-157-166
- ID: 628
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Abstract
Gangliosides are complex glycosphingolipids which contain ceramide and various oligosaccharides usually bearing sialic acids. An interesting feature of gangliosides is that their quantitative and qualitative composition changes during oncogenesis. This process is specific and depends on the histological type of a tumor and its functional status even within one neoplasm. On the other hand, latest advances in understanding structural and functional organization of glycosphingolipids, and primarily insights into lipid raft formation, showed that gangliosides may take part in the regulation of the activity of kinases mediating the modulation of signaling pathways involved in the malignant potential of cells. This article describes basic concepts of gangliosides and their biological role in signaling pathways involved in tumor development. We focused on experimental studies revealing both inhibitory and activating effects on important protein receptors responsible for cell proliferation, differentiation and death.
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About the authors
N. S. Ivanov
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
Author for correspondence.
Email: greatinsmd@gmail.com
ORCID iD: 0000-0002-9927-8445
Nikolay S. Ivanov, a pediatrician, a resident in Pediatric Oncology
1 Samory Mashela St., Moscow 117997
Russian FederationR. V. Kholodenko
M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
ORCID iD: 0000-0001-6083-6588
Moscow
Russian FederationD. Yu. Kachanov
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0002-3704-8783
Moscow
Russian FederationS. S. Larin
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0002-2128-0078
Moscow
Russian FederationM. D. Mollaev
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0003-0539-6393
Moscow
Russian FederationT. V. Shamanskaya
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
ORCID iD: 0000-0002-3767-4477
Moscow
Russian FederationReferences
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