Red blood cells contribution in blood coagulation

I. A. Chabin; Чабин И. А.; N. A. Podoplelova; Подоплелова Н. А.; M. A. Panteleev; Пантелеев М. А.

doi:10.24287/1726-1708-2022-21-3-136-141

Red blood cells contribution in blood coagulation

Authors: Chabin I.A.¹^,2, Podoplelova N.A.¹^,3, Panteleev M.A.¹^,3
Affiliations:
1. Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
2. Sechenov First Moscow State Medical University (Sechenov University)
3. Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences
Issue: Vol 21, No 3 (2022)
Pages: 136-141
Section: LITERATURE REVIEW
Submitted: 15.10.2022
Accepted: 15.10.2022
Published: 15.10.2022
URL: https://hemoncim.com/jour/article/view/659
DOI: https://doi.org/10.24287/1726-1708-2022-21-3-136-141
ID: 659

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Abstract

For a long time, red blood cells have been known to have a procoagulant effect on hemostatic system. This effect was usually ascribed to either general increase of blood viscosity due to increased hematocrit value, RBCs' transport-enhancing effect on platelets adhesion under flow conditions. It is known that red blood cells can have a procoagulant effect on the hemostasis system. This effect is usually explained either by a general increase in blood viscosity due to an increase in hematocrit, or by the effect of red blood cells on the transport of platelets to the vessel wall and their further adhesion. However, recent studies indicate that the role of red blood cells in blood coagulation is much wider. In this review, we will consider the main mechanisms currently known, through which red blood cells can influence the processes of hemostasis and thrombosis in normal and pathological conditions.

Keywords

red blood cells, blood coagulation, thrombosis

About the authors

I. A. Chabin

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation; Sechenov First Moscow State Medical University (Sechenov University)

Moscow

Russian Federation

N. A. Podoplelova

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation; Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences

Author for correspondence.
Email: podoplelovan@yandex.ru

Nadezhda A. Podoplelova, PhD, leading researcher of the Laboratory of Cell Hemostasis and Thrombosis

1 Samory Mashela St., Moscow 117997, Russia

Russian Federation