Email this article Implementation of the algorithm of empirical antibacterial therapy for febrile neutropenia in the Сenter of pediatric hematology/oncology
- Authors: Solopova G.G.1, Novichkova G.A.1
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Affiliations:
- Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation
- Issue: Vol 16, No 3 (2017)
- Pages: 35-47
- Section: Статьи
- Submitted: 10.08.2018
- Published: 10.08.2017
- URL: https://hemoncim.com/jour/article/view/66
- DOI: https://doi.org/10.24287/1726-1708-2017-16-3-35-47
- ID: 66
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Abstract
Febrile neutropenia is a life-threatening condition that requires the immediate administration of broad-spectrum antibiotics. On the other hand, the most serious problem of medicine is the continuously growing resistance of microorganisms to antibiotics. It is known that the main reason for this phenomenon is the irrational and excessive use of antibacterial drugs in the hospital. To make treatment of infectious complications more effective, optimize use of antibiotics and reduce resistance of microorganisms in Dmitry Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology (Center) the algorithm for empirical antibacterial therapy of febrile neutropenia was developed. Analysis of early results showed a reduction in the consumption of all classes antibiotics in the intensive care unit (ICU) a year after the start of the algorithm. After three years, it was possible to reduce the consumption of β-lactams, fluoroquinolones and linezolid throughout the Center. When analyzing the level of resistance to antibiotics, its decrease for such pathogens as Kl. pneumoniae, Ps. aeruginosae and Ent. Cloacae was revealed. To obtain other results of the algorithm, further detailed analysis is needed.
About the authors
G. G. Solopova
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation
Author for correspondence.
Email: galina.solopova@fcchomoscow.ru
MD, PhD, head of infection prevention & control department
Russia 117997, Moscow, Samory Mashela st., 1 Tel.: +7 (495) 287-6570, ext. 1345
Russian FederationG. A. Novichkova
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation
ORCID iD: 0000-0002-2322-5734
Russian Federation
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