Dynamics of platelet functional activity and hemostatic status in a child with chronic immune thrombocytopenia on romiplostim treatment

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Abstract

Immune thrombocytopenia (ITP) is characterized by changes in both quantity and quality of platelets. As a result, severity of bleeding does not always correllate with the degree of thrombocytopenia, The quality of platelets on treatment becomes difficult to evaluate. The most promising method to investigate quality of platelets in ITP is flow cytometry. Here we describe a clinical case of monitoring of a pediatric ITP patient status on romiplostim treatment for 50 weeks using flow cytometry for platelet functional activity control.

About the authors

E. V. Suntsova

Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation

ORCID iD: 0000-0001-8404-1800
Russia 117997, Moscow, Samory Mashela st., 1 Russian Federation

A. A. Ignatova

Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation

Russia 117997, Moscow, Samory Mashela st., 1 Russian Federation

A. V. Pshonkin

Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation

ORCID iD: 0000-0002-2057-2036
Russia 117997, Moscow, Samory Mashela st., 1 Russian Federation

I. V. Serkova

Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation

Russia 117997, Moscow, Samory Mashela st., 1 Russian Federation

A. A. Maschan

Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation

Russia 117997, Moscow, Samory Mashela st., 1 Russian Federation

G. A. Novichkova

Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation

ORCID iD: 0000-0002-2322-5734
Russia 117997, Moscow, Samory Mashela st., 1 Russian Federation

M. A. Panteleev

Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation

Author for correspondence.
Email: mapanteleev@yandex.ru
ORCID iD: 0000-0002-8128-7757

PhD, DSc, Head of the Laboratory of cellular hemostasis and trombosis

Russia 117997, Moscow, Samory Mashela st., 1

+7 (495) 287-6570, ext. 6932

Russian Federation

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Copyright (c) 2017 Suntsova E.V., Ignatova A.A., Pshonkin A.V., Serkova I.V., Maschan A.A., Novichkova G.A., Panteleev M.A.

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This work is licensed under a Creative Commons Attribution 4.0 International License.