Anthracycline-induced cardiotoxicity in a child with acute lymphoblastic leukaemia against the background of new coronavirus infection

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Abstract

Anthracycline chemotherapy drugs are widely used for the treatment of various tumors but they are associated with high cardiotoxicity. The novel coronavirus disease can also negatively affect the heart function. In this article, we report a case of anthracycline-related cardiotoxicity in a child with refractory acute lymphoblastic leukemia and the novel coronavirus disease, describing changes in instrumental and laboratory parameters observed over time during the treatment and providing a description of autopsy samples of the myocardium. The patient’s parents gave their consent to the use of their child's data, including photographs, for research purposes and in publications.

About the authors

G. V. Kondratiev

Saint Petersburg State Pediatric Medical University of the Ministry of Healthcare of the Russian Federation

Author for correspondence.
Email: spbgvk@mail.ru
ORCID iD: 0000-0002-1462-6907

Gleb V. Kondratiev - a pediatric oncologist, an assistant lecturer at the Department of Oncology, Pediatric Oncology and Radiation Therapy.

2 Litovskaya St., 194100, St. Petersburg

Russian Federation

M. E. Melnikov

Saint Petersburg State Pediatric Medical University of the Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0003-4744-0882

St. Petersburg

Russian Federation

S. A. Kulyova

Saint Petersburg State Pediatric Medical University of the Ministry of Healthcare of the Russian Federation; N.N. Petrov National Medical Research Center of Oncology of the Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0003-0390-8498

St. Petersburg

Russian Federation

A. S. Chepelev

Saint Petersburg State Pediatric Medical University of the Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0002-4127-3457

St. Petersburg

Russian Federation

S. L. Bannova

Saint Petersburg State Pediatric Medical University of the Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0003-1351-1910

St. Petersburg

Russian Federation

T. L. Kornishina

Saint Petersburg State Pediatric Medical University of the Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0002-6238-4121

St. Petersburg

Russian Federation

I. A. Reshetnyak

Saint Petersburg State Pediatric Medical University of the Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0001-5047-1749

St. Petersburg

Russian Federation

K. D. Murasheva

Saint Petersburg State Pediatric Medical University of the Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0003-2674-1440

St. Petersburg

Russian Federation

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Copyright (c) 2023 Kondratiev G.V., Melnikov M.E., Kulyova S.A., Chepelev A.S., Bannova S.L., Kornishina T.L., Reshetnyak I.A., Murasheva K.D.

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This work is licensed under a Creative Commons Attribution 4.0 International License.