The overview of fibrinolysis system contemporary concepts and of its disorders diagnostic methods

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Abstract

Fibrinolysis is an important biochemical process responsible for the dissolution of fibrin clots, which appear during the blood coagulation process. Disorders in fibrinolysis system may result in life-threatening conditions like thrombosis and bleedings. At this time, we know a lot about the molecular mechanism of fibrinolysis, all reactions are described in details, and yet its regulation and evaluation of fibrinolysis state are still unclear. In this review we analyze the information about how fibrinolysis functions and what disorders of this system can be met. We describe in details the methods used to evaluate the state of fibrinolysis system.

About the authors

A. S. Zhalyalov

Center for Theoretical Problems of Physicochemical Pharmacology RAS

Author for correspondence.
Russian Federation

A. N. Balandina

Center for Theoretical Problems of Physicochemical Pharmacology RAS
National Scientific and Practical Centre of Pediatric Hematology, Oncology and Immunology n.a. D. Rogachev"

Russian Federation

A. D. Kuprash

Center for Theoretical Problems of Physicochemical Pharmacology RAS
National Scientific and Practical Centre of Pediatric Hematology, Oncology and Immunology n.a. D. Rogachev"

Russian Federation

A. Srivastava

Christian Medical College, Vellore, India

India

A. M. Shibeko

Center for Theoretical Problems of Physicochemical Pharmacology RAS

Email: alshibeko@gmail.com

PhD in biophysics, leading researcher, Laboratory of Cell Physiology and Biophysics

+7 (495) 938-2533

Russian Federation

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Copyright (c) 2017 Zhalyalov A.S., Balandina A.N., Kuprash A.D., Srivastava A., Shibeko A.M.

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