Evolution of therapy for acute lymphoblastic leukemia in children: Empirical, biological, and organizational aspects

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Abstract

The paper presents the main stages in the evolution of therapy for acute lymphoblastic leukemia (ALL) in children and adolescents all over the world and in Russia and outlines the history of BFM-oriented protocols. The formation of the national cooperative group for ALL treatment in Russia and the creation of Moscow-Berlin protocols are described and approaches to optimization of ALL therapy in children and adolescents in Russia are presented.

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A. G. Rumyantsev

Federal Research Center of Pediatric Hematology, Oncology, and Immunology named after Dmitry Rogachev

Author for correspondence.
Email: Alexander.Rumyantsev@fccho-moscow.ru
Russian Federation

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Copyright (c) 2015 Rumyantsev A.G.

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