Email this article A morphometric analysis of platelets using transmission electron microscopy
- Authors: Kuznetsova A.A.1, Kireev I.I.2, Obydennyi S.I.1,3
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Affiliations:
- Center for Theoretical Problems of Physicochemical Pharmacology, RAS
- Lomonosov Moscow State University
- Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of the Ministry of Healthcare of the Russian Federation
- Issue: Vol 23, No 2 (2024)
- Pages: 140-144
- Section: ORIGINAL ARTICLES
- Submitted: 22.07.2024
- Published: 08.07.2025
- URL: https://hemoncim.com/jour/article/view/871
- DOI: https://doi.org/10.24287/1726-1708-2024-23-2-140-144
- ID: 871
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Abstract
Platelets are the second most abundant human blood cells. They have an important function to form blood clots at sites of vascular injury to prevent bleeding. Abnormalities of platelet structure can lead to various dysfunctions and life-threatening situations. In some hereditary platelet disorders, morphological examination of platelets with transmission electron microscopy (TEM) may be required. TEM is technically complex, and its use is limited due to the need for expensive equipment and trained personnel. In our study, we assessed the morphometric parameters of platelets obtained from 20 healthy donors using TEM. The study was approved by the Independent Ethics Committee and the Scientific Council of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology.
About the authors
A. A. Kuznetsova
Center for Theoretical Problems of Physicochemical Pharmacology, RAS
ORCID iD: 0009-0003-7209-945X
Moscow
Russian FederationI. I. Kireev
Lomonosov Moscow State University
ORCID iD: 0000-0001-9252-6808
Moscow
Russian FederationS. I. Obydennyi
Center for Theoretical Problems of Physicochemical Pharmacology, RAS;Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of the Ministry of Healthcare of the Russian Federation
Author for correspondence.
Email: obydennyj@physics.msu.ru
ORCID iD: 0000-0002-2930-8768
Sergey I. Obydennyi, a researcher at the Laboratory of Cell Hemostasis and Thrombosis, Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation
1 Samory Mashela St., 117997, Moscow, Russia
Russian FederationReferences
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