Experience in the treatment of young adults with acute lymphoblastic leukemia by ALL-MB-Minsk 2010 protocol

Modified pediatric ALL-MB 2008 protocol - protocol ALL-MB-Minsk 2010 was used in the treatment of young adults (18-29 years) with acute lymphoblastic leukemia (ALL) from January 2010 to December 2014. The study group consisted of 47 patients aged 18-29 years (median 22.2 years). Complete remission was attained in 46 (97.9%) patients. Six (12.7%) patients developed relapses. Seven (15.2%) patients died: 1 during induction therapy, 3 from infectious complications in complete remission, and 3 from the disease progression in relapse. 5-Year event-free survival was 68 ± 10%, 5-year overall survival - 84 ± 6%, with the observation median of 2.2 years. The results demonstrate the efficacy of ALL-MB-Minsk 2010 protocol in therapy of young adults with ALL.

лица молодого возраста, острый лимфобластный лейкоз, протокол ALL-MB-Minsk 2010, выживаемость, young adults, acute lymphoblastic leukemia, ALL-MB-Minsk 2010 protocol, survival