Vitamin K-dependent coagulopathy in neonates and infants

Cover Page

Cite item

Full Text

Abstract

Vitamin K-dependent coagulopathy caused by vitamin K deficiency holds an important place among bleeding disorders in newborns and infants. The late type of this disease is considered to be the most dangerous one because up to 50% of children develop intracranial hemorrhage which often leads to disability or even death if diagnosis is delayed. Here, we report on the prevalence, treatment and prevention of vitamin K-dependent coagulopathy in neonates and infants.

About the authors

E. M. Golovina

The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation;
Regional Children’s Clinical Hospital

Author for correspondence.
Email: golovinhelen@yandex.ru
ORCID iD: 0000-0003-4452-5821

Elena M. Golovina, a research technician at the Laboratory of Hemostasis Disorders at the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation; a hematologist at the Department of Pediatric Oncology and Hematology with Chemotherapy at Regional Children’s Clinical Hospital

339 Rifle Division St. 14, Rostov-on-Don 344015

Russian Federation

К. S. Aslanyan

Regional Children’s Clinical Hospital

ORCID iD: 0000-0002-3635-8579

Rostov-on-Don

Russian Federation

References

  1. Newman P., Shearer M.J. Vitamin K metabolism. Subcell Biochem 1998; 30: 455–88. doi: 10.1007/978-1- 4899-1789-8_19
  2. Shearer M.J. Vitamin K metabolism and nutriture. Blood Rev 1992; 6: 92–104. doi: 10.1016/0268-960X(92)90011-E
  3. Clarke P., Mitchell S.J., Shearer M.J. Total and differential phylloquinone (vitamin K1 ) intakes of preterm infants from all sources during the neonatal period. Nutrients 2015; 7 (10): 8308–20. doi: 10.3390/nu7105393
  4. Cornelissen M., von Kries R., Loughnan P., Schubiger G. Prevention of vitamin K deficiency bleeding: Efficacy of different multiple oral dose schedules of vitamin K. Eur J Pediatr 1997; 156: 126–30. doi: 10.1007/s004310050570
  5. Ardell S., Offringa M., Ovelman C., Soll R. Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates. Cochrane Database Syst Rev 2018; 2: CD008342.
  6. Zipursky A. Prevention of vitamin K deficiency bleeding in newborns. Br J Haematol 1999; 104: 430–7. doi: 10.1046/j.1365-2141.1999.01104.x
  7. Araki S., Shirahata A. Vitamin K Deficiency Bleeding in Infancy. Nutrients 2020; 12 (3): 780. doi: 10.3390/nu12030780
  8. Centers for Disease Control and Prevention (CDC). Notes from the field: late vitamin K deficiency bleeding in infants whose parents declined vitamin K prophylaxis – Tennessee, 2013. MMWR Morb Mortal Wkly Rep 2013; 62 (45): 901–2.
  9. Townsend C.W. The haemorrhagic disease of the newborn. Arch Paediatr 1894; 11: 559–65.
  10. Dam H. Vitamin K, its discovery, biochemistry and application in medicine. J Mt Sinai Hosp N Y 1946; 12: 961–70.
  11. Dam H., Dyggve H., Larsen H., Plum P. The relation of vitamin K deficiency to hemorrhagic disease of the newborn. Adv Pediatr 1952; 5: 129–53.
  12. Jullien S. Vitamin K prophylaxis in newborns. BMC Pediatr 2021; 21 (Suppl 1): 350. doi: 10.1186/s12887-021-02701-4
  13. Sankar M., Chandrasekaran A., Kumar P., Thukral A., Agarwal R., Paul V.K. Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: a systematic review. J Perinatol 2016; 36 (Suppl 1): S29–35. doi: 10.1038/jp.2016.30
  14. Higuera-Cetina C.I., MontañaGómez L.M., Picón-Jaimes Y.A., Orozco-Chinome J.E., Lozada-Martínez I.D., Moscote-Salazar L.R. Late-Onset Vitamin K Deficiency Bleeding: A Preventable Pathology. J Pediatr Hematol Oncol 2021; 43 (8): e1272–3. doi: 10.1097/MPH.0000000000002315
  15. Bhanchet P., Tuchinda S., Hathirat P., Visudhiphan P., Bhamaraphavati N., Bukkavesa S. A bleeding syndrome in infants due to acquired prothrombin complex deficiency: A survey of 93 affected infants. Clin Pediatr (Phila) 1977; 16: 992–8. doi: 10.1177/000992287701601106
  16. Clinical recommendations for diagnosis and treatment of hemolytic disease of the newborn. М.: Neonatology Association; 2015. [Electronic resource] URL: https://babymed73.ru/upload/medialibrary/b48/b48d7b487be26fb640ef0291c2 e4af2a.pdf (access date: 24.10.2024). (In Russ.)
  17. Hanawa Y., Maki M., Murata B., Matsuyama E., Yamamoto Y., Nagao T., et al. The second nation-wide survey in Japan of vitamin K deficiency in infancy. Eur J Pediatr 1988; 147: 472–7. doi: 10.1007/BF00441969
  18. Schulte R., Jordan L.C., Morad A., Naftel R.P., Wellons J.C., Sidonio R. Rise in Late Onset Vitamin K Deficiency Bleeding in Young Infants Because of Omission or Refusal of Prophylaxis at Birth. Pediatr Neurol 2014; 50: 564–8.
  19. von Kries R., Hanawa Y. Neonatal vitamin K prophylaxis. Report of Scientific and Standardization Subcommittee on Perinatal Haemostasis. Thromb Haemost 1993; 69: 293–5.
  20. Elalfy M., Eltonbary K., Elalfy O., Gadallah M., Zidan A., AbdelHady H. Intracranial haemorrhage associated with Vitamin K deficiency in Egyptian infants. Acta Paediatr 2021; 110 (11): 2937–43. doi: 10.1111/apa.16011
  21. Al-Zuhairy S.H. Late vitamin K deficiency bleeding in infants: five-year prospective study. J Pediatr (Rio J) 2021; 97 (5): 514–9. doi: 10.1016/j.jped.2020.09.003
  22. Vikasol package insert. [Electronic resource] URL: https://grls.pharm-portal.ru/grls/f91087d4-4eaf406b-891a-48d0efcfc475#dosageForms (access date: 24.10.2024). (In Russ.)
  23. Shearer M.J. Vitamin K deficiency bleeding (VKDB) in early infancy. Blood Rev 2009; 23: 49–59. doi: 10.1016/j.blre.2008.06.001
  24. Lembo C., Buonocore G., Perrone S. The challenge to define the optimal prophylactic regimen for vitamin K deficiency bleeding in infants. Acta Paediatr 2021; 110 (4): 1113–8. doi: 10.1111/apa.15566
  25. American Academy of Pediatrics. Report of the Committee on Nutrition: vitamin K compounds and the water-soluble analogues. Pediatrics 1961; 28: 501–6.
  26. American Academy of Pediatrics Vitamin K Ad Hoc Task Force. Controversies concerning vitamin K and the newborn. Pediatrics 1993; 91: 1001–3.
  27. American Academy of Pediatrics Committee on Fetus and Newborn. Controversies concerning vitamin K and the newborn. American Academy of Pediatrics Committee on Fetus and Newborn Pediatrics 2003; 112: 191–2.
  28. Darlow B.A., Phillips A.A., Dickson N.P. New Zealand surveillance of neonatal vitamin K deficiency bleeding (VKDB): 1998–2008. J Paediatr Child Health 2011; 47: 460–4.
  29. Busfield A., Samuel R., McNinch A., Tripp J.H. Vitamin K deficiency bleeding after NICE guidance and withdrawal of Konakion Neonatal: British Paediatric Surveillance Unit study. Arch Dis Child 2013; 98: 41–7.
  30. World Health Organization. WHO recommendations on newborn health. Guidelines approved by the WHO guidelines review committee. Geneva; 2017. [Electronic resource] URL: https://apps.who.int/iris/bitstream/handle/10665/259269/WHO-MCA-17.07-eng.pdf;jsessionid=CF264F9448EAE361B5BE63F6B8BD284B?sequence=1 (cited 2019 Jun 10).
  31. World Health Organization. Recommendations for management of common childhood conditions: evidence for technical update of pocket book recommendations. 2012. [Electronic resource] URL: https://apps.who.int/iris/bitstream/handle/10665/44774/9789241502825_eng.pdf?sequence=1 (cited 2019 Jun 25).
  32. American Academy of Pediatrics. AAP publications reaffirmed or retired. Pediatrics 2020; 145 (6): 2020–2.
  33. Schubiger G., Berger T.M., Weber R., Bänziger O., Laubscher B.; Swiss Paediatric Surveillance Unit. Prevention of vitamin K deficiency bleeding with oral mixed micellar phylloquinone: results of a 6-year surveillance in Switzerland. Eur J Pediatr 2003; 162: 885–8.
  34. von Kries R., Hachmeister A., Göbel U. Oral mixed micellar vitamin K for prevention of late vitamin K deficiency bleeding. Arch Dis Child Fetal Neonatal Ed 2003; 88: F109–12.
  35. Federal clinical guidelines for diagnosis and treatment of hemorrhagic disease of the newborn. M.: Dmitry Rogachev NMRCPHOI of Ministry of Healthcare of Russia, National Society of Pediatric Hematologists and Oncologists of Russia; 2014. [Electronic resource] URL: http://nodgo.org/sites/default/files/ФКР%20по%20диагностике%20и%20лечению20геморрагической%20болезни%20новорожденных.pdf (access date: 24.10.2024). (In Russ.)
  36. Chawla D., Deorari A.K., Saxena R., Paul V.K., Agarwal R., Biswas A., Meena A. Vitamin K1 versus vitamin K3 for prevention of subclinical vitamin deficiency: a randomized controlled trial. Indian Pediatr 2007; 44 (11): 817–22.
  37. Dyggve H.V., Dam H., Søndergaard E. Comparison of the action of vitamin K1 with that of synkavit in the newborn. Acta Paediatr (Stockh) 1954; 43 (1): 27–31. doi: 10.1111/j.1651-2227.1954.tb03995.x
  38. Greer F.R. Controversies in neonatal nutrition: macronutrients and micronutrients. In: Gastroenterology and nutrition: neonatology question and controversies. 2nd ed. by Neu J. Philadelphia: Elsevier saunders; 2012. Pp. 129–155.
  39. Mihatsch W.A., Braegger C., Bronsky J., Campoy C., Domellöf M., Fewtrell M., et al.; ESPGHAN Committee on Nutrition. Prevention of Vitamin K Deficiency Bleeding in Newborn Infants: A Position Paper by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr 2016; 63 (1): 123–9. doi: 10.1097/MPG.0000000000001232
  40. Takahashi D., Shirahata A., Itoh S., Takahashi Y., Nishiguchi T., Matsuda Y. Vitamin K prophylaxis and late vitamin K deficiency bleeding in infants: fifth nationwide survey in Japan. Pediatr Int 2011; 53 (6): 897–901. doi: 10.1111/j.1442-200X.2011.03392.x
  41. Sutor A.H., Dagres N., Niederhoff H. Late form of vitamin K deficiency bleeding in Germany. Klin Padiatr 1995; 207 (3): 89–97. doi: 10.1055/s-2008-1046519
  42. Autret-Leca E., Jonville-Bera A.P. Vitamin K in neonates: how to administer, when and to whom. Paediatr Drugs 2001; 3: 1–8.
  43. Yilmaz C., Yuca S.A., Yilmaz N., Bektaş M.S., Caksen H. Intracranial hemorrhage due to vitamin K deficiency in infants: a clinical study. Int J Neurosci 2009; 119 (12): 2250–6. doi: 10.3109/00207450903170437
  44. Zaplatnikov A.L., Brazhnikova O.V., Gavelya N.V., Nikitin V.V., Ashurova B.A., Koroleva A.S., et al. To the question of “late hemorrhagic disease of the newborn”. Russian Medical Journal 2017; (19): 1331–4. (In Russ.)

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2024 Golovina E.M., Aslanyan К.S.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.