Email this article Acquired aplastic anemia in children in Republic of Belarus: epidemiology and etiology
- Authors: Kugeiko T.V.1, Budanov O.I.1
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Affiliations:
- Belorusian Research Center for Pediatric Oncology, Hematology and Immunology
- Issue: Vol 17, No 1 (2018)
- Pages: 29-36
- Section: Статьи
- Submitted: 09.08.2018
- Published: 09.02.2018
- URL: https://hemoncim.com/jour/article/view/24
- DOI: https://doi.org/10.24287/1726-1708-2018-17-1-29-36
- ID: 24
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Abstract
It presents the results of the first stage of the epidemiological study of acquired aplastic anemia in children (0–17 years) in the Republic of Belarus for the period 1990–2015. The study was conducted for the first time. In the Republic of Belarus the acquired aplastic anemia in the population was more often recorded in boys than in girls: 76 and 52 cases respectively (p = 0,03). Peaks of disease were determined. The acquired aplastic anemia in the age groups 5–9 years (II) and 10–14 years (III) was registered more often than in the age groups 0–4 years (I) and 15–17 years (IV) (pI–II = 0,028, pI-III = 0.0042, pII–IV = 0.0001, pIII–IV = 0.002). This increase was due to the boys. The incidence rate in the republic for the analyzed period was 0.228 ± 0.020 per 100000 with an annual increase of 1,93%. This indicator corresponds to the European one. High growth rates were recorded in Minsk and the Minsk region: 5.12 and 4.95% per year respectively. The geoinformation model identified large areas within the seven main regions of the Republic of Belarus where cases of acquired aplastic anemia were not detected. These areas are located in both "clean" areas and in the territories affected by the Chernobyl nuclear power plant accident. Therefore the data of patients will be analyzed taking into account the data of the “The State Register of Belorussian persons exposed to radiation due to the Chernobyl accident" in the second stage. The cases of acquired aplastic anemia with revealed etiology were 32%. Hepatitis-associated acquired aplastic anemia accounted for 18% of cases. In recent years, a statistically significant (p = 0.0019) decrease in cases of hepatitis-associated acquired aplastic anemia occurred.
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About the authors
T. V. Kugeiko
Belorusian Research Center for Pediatric Oncology, Hematology and Immunology
Author for correspondence.
Email: Kugeiko@oncology.by
ORCID iD: 0000-0002-2573-6810
MD, the head of Department for Clinical and Epidemiological analysis
Republic of Belarus, 223053, Minsk region, v. Borovljany, Frunze str., 43
+375 (0)17 265-40-48
O. I. Budanov
Belorusian Research Center for Pediatric Oncology, Hematology and ImmunologyBelarus
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