The value of the laboratory information system in the control of the haploidentical haematopoietic stem cells transplantation using TCRaß/CD19 depletion

Maria S. Fadeeva; Фадеева Мария Сергеевна; Elena V. Boyakova; Боякова Елена Викторовна; Yuliya V. Starichkova; Старичкова Юлия Викторовна; Dmitrii E. Pershin; Першин Дмитрий Евгеньевич; Kirill A. Voronin; Воронин Кирилл Александрович; V. A. Zubachenko; Зубаченко Виктория Андреевна; Mikhail A. Maschan; Масчан Михаил Александрович; Alexandr G. Rumyantsev; Румянцев Александр Григорьевич

doi:10.24287/1726-1708-2016-15-4-89-96

The value of the laboratory information system in the control of the haploidentical haematopoietic stem cells transplantation using TCRaß/CD19 depletion

Authors: Fadeeva M.S.¹, Boyakova E.V.¹, Starichkova Y.V.¹, Pershin D.E.¹, Voronin K.A.¹, Zubachenko V.A.¹, Maschan M.A.¹, Rumyantsev A.G.¹
Affiliations:
1. Dmitry Rogachev Federal Research Center of Pediatric Hematology, Oncology and Immunology
Issue: Vol 15, No 4 (2016)
Pages: 89-96
Section: КЛИНИЧЕСКИЕ ЛАБОРАТОРНАЯ ДИАГНОСТИКА
Submitted: 19.09.2018
Published: 19.12.2016
URL: https://hemoncim.com/jour/article/view/138
DOI: https://doi.org/10.24287/1726-1708-2016-15-4-89-96
ID: 138

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Abstract

Historical aspects of the development and optimization of the haploidentical hematopoietic stem cells transplantation and its advantages in the modern era are presented in the article. The TCRaß/CD19 depletion laboratory analysis technology using flow cytometry including a discription of the method before and after immuno-magnetic separation on the unit CliniMACSPlusSystem is shown. Methodology of application of the flow cytometric data collection and analysis protocol of the TCRaß/CD19 depletion and its integration with the laboratory information system in Laboratory of the Transplant Immunology and Immunotherapy of Hemoblastosis, Federal Scientific Clinical Centre of Pediatric Hematology Oncology Immunology named after Dmitry Rogachev Ministry of Health of the Russian Federation are presented. The results of laboratory data analysis including TCRaß/CD19 depletion quality assessment are also shown.

Keywords

гаплоидентичная трансплантация гемопоэтических стволовых клеток, деплеции TCRaß/CD19, проточная цитометрия, научно-клинические исследования, лабораторная информационная система _биологии трансплантации гемопоэтических стволовых клеток, haploidentical haematopoietic stem cells transplantation, TCRaß/CD19 depletion, flow cytometry, scientific clinical studies, laboratory information system biology of haematopoietic stem cells transplantation

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The value of the laboratory information system in the control of the haploidentical haematopoietic stem cells transplantation using TCRaß/CD19 depletion

Full Text

Abstract

Keywords

About the authors

References

Supplementary files