Pathogen inactivation technologies and quality of platelet concentrates (Review of literature)

Platelet concentrate (PC) transfusion is practically the only fast and universal way of correcting platelet function in a broad range of clinical situations in paediatric haematology. Due to a short storage time of PC, technologies of pathogen inactivation are very important for decreasing the risks of immune responses and infections. There are numerous studies indicating that platelet function can change in pathogen inactivation. The article offers a literature review of laboratory and clinical studies aimed at assessment of the significance and direction of these changes, and also discusses practical implications of such studies for clinical work with PC.

технологии инактивации патогенов, тромбоциты, функциональная активность тромбоцитов, pathogen inactivation technologies, platelets, platelet functional activity