Lung metastases in childhood neuroblastoma

T. V. Shamanskaya; Шаманская Т.В.; D. Y. Kachanov; Качанов Д.Ю.; V. I. Lihotkina; Лихоткина В.И.; G. V. Tereschenko; Терещенко Г.В.; E. S. Ternovaya; Терновая Е.С.; A. P. Shcherbakov; Щербаков А.П.; Y. N. Likar; Ликарь Ю.Н.; V. Y. Roschin; Рощин В.Ю.; Y. V. Olshanskaya; Ольшанская Ю.В.; A. N. Kazakova; Казакова А.Н.; S. R. Varfolomeeva; Варфоломеева С.Р.

doi:10.24287/1726-1708-2018-17-2-92-102

Lung metastases in childhood neuroblastoma

Authors: Shamanskaya T.V.¹, Kachanov D.Y.¹, Lihotkina V.I.¹, Tereschenko G.V.¹, Ternovaya E.S.¹, Shcherbakov A.P.¹, Likar Y.N.¹, Roschin V.Y.¹, Olshanskaya Y.V.¹, Kazakova A.N.¹, Varfolomeeva S.R.¹
Affiliations:
1. Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology
Issue: Vol 17, No 2 (2018)
Pages: 92-102
Section: ORIGINAL ARTICLES
Submitted: 20.09.2018
Published:
URL: https://hemoncim.com/jour/article/view/180
DOI: https://doi.org/10.24287/1726-1708-2018-17-2-92-102
ID: 180

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Abstract

Lung metastases in patients with neuroblastoma (NB) are an extremely rare situation. Such patients have a worse prognosis and more aggressive clinical behavior of the underlying disease. This article presents an analysis of the epidemiological, clinical, radiologic features and prognosis of the disease in a group of patients with stage 4 NB and lung metastases. The cohort of NB patients with stage 4 according to the International Neuroblastoma Staging System (INSS) treated in NRC PHOI named after Dmitry Rogachev for the period 01.2012–12.2016 (60 months) was included in the analysis. Patients were stratified and treated according to the modified protocol NB-2004. Comparative analysis of patients with high-risk NB with and without lung metastases was done. Estimated event-free and overall survival were determined using Kaplan–Meier methods. Among 132 patients with stage 4 NB lung metastases were detected in 10 cases, which represented 7.5% of the whole group. The median age of the patients with lung metastases was 26.4 months (range 4.3–92.5). 9 (90%) patients were stratified to highrisk group, 1 (10%) to intermediate risk group. Comparative analysis of patients with stage 4 high-risk NB with and without lung metastases showed no statistical difference in comparison by sex, age, localization of the primary tumor, MYCN status, and the number of metastatic compartments. Progression during induction therapy was more frequent in patients with lung metastases (p = 0.02). 2-year overall survival (OS) in the group of patients with lung metastases was lower than in group without metastases to the lung (50.0 ± 15.8% vs 75.9 ± 3.9%, p = 0.045). In our study, the presence of lung metastases was more common than was described elsewhere and is clinically important because it portends a poor prognosis.

Keywords

neuroblastoma, children, lung metastases, 123I-metaiodobenzylguanidine scintigraphy, computed tomography, survival

About the authors

T. V. Shamanskaya

Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology

Email: shamanskay.tatyana@gmail.com
ORCID iD: 0000-0002-3767-4477

MD, scientific secretary, Institute of oncology, radiology and nuclear medicine

Russia 117997, Moscow, Samory Mashela st., 1
Tel.: +7 (495) 287-6570

Russian Federation

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