Association between congenital heart disease and neuroblastoma in children

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Abstract

We have analyzed the association between the most common extracranial solid tumor of childhood neuroblastoma (NB) and congenital heart disease (CHD) based on our own data and literature review. The analyses was carried out based on medical history and  echocardiography data of NB patients, who received medical treatment in Dmitriy Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology. 11 out of 457 patients with NB had CHD, the most common diagnosis was ventricular septal defect. The epidemiologic data of the cohort of patients with CHD and NB was presented. The article contains detailed description of two patients with CHD and localized and metastatic NB. The comprehensive analysis of the existing literature was done. In conclusion, CHD was observed in 2,4% cases. All patients with NB are required cardiologic assessment including echocardiography.

About the authors

T. V. Shamanskaya

Institute of oncology, radiology and nuclear medicine; Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation

Author for correspondence.
Email: shamanskaya.tatyana@gmail.com
ORCID iD: 0000-0002-3767-4477

Tatyana V. Shamanskaya, MD, scientific secretary

117997, Moscow, Samory Mashela st., 1

Russian Federation

M. M. Burgol

Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation

ORCID iD: 0000-0002-1925-2457
Russian Federation

D. Yu. Kachanov

Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation

ORCID iD: 0000-0002-3704-8783
Russian Federation

N. A. Rybalko

Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation

Russian Federation

L. L. Pankratieva

Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation

Russian Federation

A. B. Sugak

Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation

Russian Federation

E. V. Feoktistova

Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation

Russian Federation

S. R. Varfolomeeva

Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation

Russian Federation

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Copyright (c) 2018 Shamanskaya T.V., Burgol M.M., Kachanov D.Y., Rybalko N.A., Pankratieva L.L., Sugak A.B., Feoktistova E.V., Varfolomeeva S.R.

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