Email this article Optic pathway gliomas in children: prognostic factors, response assessment, role of carboplatin and vincristine chemotherapy regime
- Authors: Valiakhmetova E.F.1, Budanov O.I.2, Gorelyshev S.K.1,3, Serova N.K.1, Lasareva L.A.1, Shiskina L.V.1, Mazerkina N.A.1, Trunin Y.Y.1, Chulkova S.V.3,4, Grishchenko N.V.3,4, Egorova A.V.3,4, Papusha L.I.2, Novichkova G.А.3,2, Karachunskii A.I.3,2
-
Affiliations:
- N.N. Burdenko National Medical Research Center of neurosurgery Ministry of Healthcare of Russian Federation
- Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation
- N.I. Pirogov Russian National Research Medical University
- N.N. Blokhin National Medical Research Center of oncology Ministry of Healthcare of Russian Federation
- Issue: Vol 18, No 1 (2019)
- Pages: 62-72
- Section: ORIGINAL ARTICLES
- Submitted: 21.04.2019
- Accepted: 21.04.2019
- Published: 21.04.2019
- URL: https://hemoncim.com/jour/article/view/227
- DOI: https://doi.org/10.24287/1726-1708-2019-18-1-62-72
- ID: 227
Cite item
Full Text
Abstract
Low grade gliomas (LGG) constitute 35-40% of all primary central nervous system (CNS) tumors in children, at least 10-12% of them affecting the optic pathway. The complexity of the localization and predominantly the diffuse type of growth of these tumors make the neurosurgical treatment not appropriate in most cases, which requires conservative treatment.
Objective: to analyze the results of carboplatin and vincristine chemotherapy (CT) regime in children with optic pathway gliomas (OPG). The study was approved by the Independent Ethics Committee of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology. In the study was included patients registered at the Burdenko Neurosurgery Institute from January 1, 2003 till December 31, 2015 with optic pathway glioma from 0 to 18 years old that were treated with combined carboplatin and vincristine chemotherapy. All patients were divided into 2 groups: the first group included patients who had newly diagnosed OPG (group 1), the second group included patients with OPG with radiological progression following observation times (group 2). Evaluation of the response to treatment was carried out on the 24th week and after completion of treatment by delineation of each slice of the MRI images in OsiriX MD software (© Pixmeo Sari, Switzerland) with subsequent automatic volume calculation.
Results: 104 patients were included in the analysis. 69 children were included to group 1, 35 patients in group 2. 60% of patients were boys, about a third of children were less than 18 months old, 17% of patients had Neurofibromatosis type I, 24% of patients had diencephalic cachexia. A biopsy of the tumor was performed in 76% of the patients, 54% of the patients had a piloid astrocytoma and 23% had a pilomixoid astrocytoma. The progression after the start of the chemotherapy was in 30 (28.9%) patients. 5-year event free survival (EFS) and overall survival (OS) were 58 ± 6% and 97 ± 2%, respectively. 5-year EFS was not statistically significantly different in patients of groups 1 and 2. According to our data, the age, histology of the tumor, the response to the 24th week of CT are independent prognostic factors.
Keywords
About the authors
E. F. Valiakhmetova
N.N. Burdenko National Medical Research Center of neurosurgery Ministry of Healthcare of Russian Federation
Author for correspondence.
Email: andgeval@gmail.com
ORCID iD: 0000-0002-2977-665X
Endge F. Valiakhmetova - MD, pediatric oncologist.
125047, Moscow, 4th Tverskaya-Yamskaya st., 16
РоссияO. I. Budanov
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation
ORCID iD: 0000-0003-3232-2322
Moscow
РоссияS. K. Gorelyshev
N.N. Burdenko National Medical Research Center of neurosurgery Ministry of Healthcare of Russian Federation; N.I. Pirogov Russian National Research Medical University
Moscow
РоссияN. K. Serova
N.N. Burdenko National Medical Research Center of neurosurgery Ministry of Healthcare of Russian Federation
Moscow
РоссияL. A. Lasareva
N.N. Burdenko National Medical Research Center of neurosurgery Ministry of Healthcare of Russian Federation
Moscow
РоссияL. V. Shiskina
N.N. Burdenko National Medical Research Center of neurosurgery Ministry of Healthcare of Russian Federation
Moscow
РоссияN. A. Mazerkina
N.N. Burdenko National Medical Research Center of neurosurgery Ministry of Healthcare of Russian Federation
Moscow
РоссияY. Y. Trunin
N.N. Burdenko National Medical Research Center of neurosurgery Ministry of Healthcare of Russian Federation
Moscow
РоссияS. V. Chulkova
N.I. Pirogov Russian National Research Medical University; N.N. Blokhin National Medical Research Center of oncology Ministry of Healthcare of Russian Federation
ORCID iD: 0000-0003-4412-5019
Moscow
РоссияN. V. Grishchenko
N.I. Pirogov Russian National Research Medical University; N.N. Blokhin National Medical Research Center of oncology Ministry of Healthcare of Russian Federation
Moscow
РоссияA. V. Egorova
N.I. Pirogov Russian National Research Medical University; N.N. Blokhin National Medical Research Center of oncology Ministry of Healthcare of Russian Federation
ORCID iD: 0000-0003-3904-8530
Moscow
РоссияL. I. Papusha
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation
ORCID iD: 0000-0001-7750-5216
Moscow
РоссияG. А. Novichkova
N.I. Pirogov Russian National Research Medical University; Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation
ORCID iD: 0000-0002-2322-5734
Moscow
РоссияA. I. Karachunskii
N.I. Pirogov Russian National Research Medical University; Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation
Moscow
РоссияReferences
Supplementary files
