Email this article BCR-ABLl-like pediatric acute lymphoblastic leukemia
- Authors: Tsaur G.A.1,2,3, Olshanskaya Y.V.4, Druy A.E.4
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Affiliations:
- Regional Children’s Hospital
- Research Institute of Medical Cell Technologies
- Ural State Medical University
- Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation
- Issue: Vol 18, No 1 (2019)
- Pages: 112-126
- Section: LITERATURE REVIEW
- Submitted: 21.04.2019
- Accepted: 21.04.2019
- Published: 21.04.2019
- URL: https://hemoncim.com/jour/article/view/233
- DOI: https://doi.org/10.24287/1726-1708-2019-18-1-112-126
- ID: 233
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Abstract
The purpose of this study is a comprehensive analysis of BCR-ABLl-like pediatric acute lymphoblastic leukemia (ALL) and to point out the difference between BCR-ABLl-like and Ph-like ALL in children. It was shown the genetic heterogeneity of BCR-ABLl-like ALL including cases with tyrosine kinase fusion genes, activating mutations in JAK-STAT, RAS. We also described various diagnostic options and prognostic role of BCR-ABL1-like ALL in children.
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About the authors
G. A. Tsaur
Regional Children’s Hospital; Research Institute of Medical Cell Technologies; Ural State Medical University
Author for correspondence.
Email: tsaur@mail.ru
ORCID iD: 0000-0002-9881-6221
Grigory А. Tsaur, MD, Doctor of Medical Science.
620149, Ekaterinburg, S. Deryabina st., 32
Russian FederationYu. V. Olshanskaya
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation
ORCID iD: 0000-0002-2352-7716
Moscow
Russian FederationA. E. Druy
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation
ORCID iD: 0000-0003-1308-8622
Moscow
Russian FederationReferences
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