Intrachromosomal amplification of chromosome 21 (iAMP21) is the marker of unfavorable prognosis in childhood B-cell precursor acute lymphoblastic leukemia

Yu. V. Olshanskaya; Ольшанская Ю.В.; A. N. Kazakova; Казакова А.Н.; A. A. Chervova; Червова А.А.; J. V. Rumiantseva; Румянцева Ю.В.; D. V. Litvinov; Литвинов Д.В.; E. A. Zerkalenkova; Зеркаленкова Е.А.; O. I. Soldatkina; Солдаткина О.И.; S. N. Lagoiko; Лагойко С.Н.; N. V. Myakova; Мякова Н.В.; G. Henze; Хенце Г. .; A. G. Rumiantsev; Румянцев А.Г.; A. I. Karachunskii; Карачунский А.И.

doi:10.24287/1726-1708-2018-17-1-37-45

Intrachromosomal amplification of chromosome 21 (iAMP21) is the marker of unfavorable prognosis in childhood B-cell precursor acute lymphoblastic leukemia

Authors: Olshanskaya Y.V.¹, Kazakova A.N.¹, Chervova A.A.¹, Rumiantseva J.V.¹, Litvinov D.V.¹, Zerkalenkova E.A.¹, Soldatkina O.I.¹, Lagoiko S.N.¹, Myakova N.V.¹, Henze G.², Rumiantsev A.G.¹, Karachunskii A.I.¹
Affiliations:
1. Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology
2. Pädiatrische Onkologie und Hämatologie Charité CVK, Universitätsmedizin Berlin
Issue: Vol 17, No 1 (2018)
Pages: 37-45
Section: Статьи
Submitted: 09.08.2018
Published: 09.02.2018
URL: https://hemoncim.com/jour/article/view/25
DOI: https://doi.org/10.24287/1726-1708-2018-17-1-37-45
ID: 25

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Abstract

Childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) with intrachromosomal amplification of chromosome 21 (iAMP21) has very unfavorable prognosis when treated according as standard risk group, mainly due to high risk of relapce. The outcome is improoving dramatically when the patients were treated as high risk. In our study we analyzed clinical parameters and outcome in children with BCP-ALL and iAMP21 according to trial Moscow-Berlin 2008 (ALL-MB 2008). The majority of patients were stratified in standard and intermediate risk group. Seven years event free survival (EFS) in patients with iAMP21 and without iAMP21 was 0.48 ± 0.24 and 0,87 ± 0,2 respectively with cumulative incidence of relapse 0.41 ± 0.24 и 0.07 ± 0.2. BCP-ALL with iAMP21 needs some changes in current stratification strategy and new approaches to treatment. For faster and accurate detection of iAMP21 evaluation by FISH technique must be applied.

Keywords

iAMP21, B precursor acute lymphoblastic leukemia, FISH, chromosome rearrangement, prognosis

About the authors

Yu. V. Olshanskaya

Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology

Author for correspondence.
Email: yuliaolshanskaya@gmail.com
ORCID iD: 0000-0002-2352-7716

M.D., Ph.D., Head of laboratory of cytogenetics and molecular genetics

Russia 117997, Moscow, Samory Mashela st., 1
+7 (495) 287-6570

Russian Federation

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