Blood coagulation in the 21st century: existing knowledge, current strategies for treatment and perspective

N. A. Podoplelova; Подоплелова Н. А.; V. B. Sulimov; Сулимов В. Б.; I. S. Ilin; Тащилова А. С.; A. S. Tashilova; Ильин И. С.; M. A. Panteleev; Пантелеев М. А.; I. V. Ledeneva; Ледeнева И. В.; Kh. S. Shikhaliev; Шихалиев Х. С.

doi:10.24287/1726-1708-2020-19-1-139-157

Blood coagulation in the 21st century: existing knowledge, current strategies for treatment and perspective

Authors: Podoplelova N.A.¹^,2, Sulimov V.B.³^,4, Ilin I.S.³^,4, Tashilova A.S.³^,4, Panteleev M.A.¹^,2^,5^,6, Ledeneva I.V.⁷, Shikhaliev K.S.⁷
Affiliations:
1. Russian Children's Clinical Hospital of the Pirogov Russian National Research Medical University of the Ministry of Healthcare of the Russian Federation
2. Center for Theoretical Problems of Physicochemical Pharmakology
3. Research Computing Center, Moscow State University
4. LLC Dimonta
5. Lomonosov Moscow State University
6. Moscow Institute of Physics and Technology (State University)
7. Voronezh State University
Issue: Vol 19, No 1 (2020)
Pages: 139-157
Section: LITERATURE REVIEW
Submitted: 28.03.2020
Accepted: 28.03.2020
Published: 28.03.2020
URL: https://hemoncim.com/jour/article/view/317
DOI: https://doi.org/10.24287/1726-1708-2020-19-1-139-157
ID: 317

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Abstract

Disorders in the blood coagulation system are the leading cause of death and disability in the modern world. So the search for new drugs that can prevent pathological thrombosis, while not affecting normal hemostasis, becomes more relevant than ever. Recent studies has been a revolution in the understanding of the principles of work and the regulation of blood coagulation. In addition, new, more effective approaches to drug development have now appeared. For example computer simulation methods that can significantly reduce the time and resources spent on the search for new candidate molecules. In the review, the blood clotting system, the molekular mechanisms of thrombosis, the role of blood coagulation factors Xa and XIa, and the urgency of developing new inhibitors of these targets are shown, and the most interesting inhibitors of factors Xa and XIa are presented.

Keywords

blood coagulation, thrombosis, anticoagulants, inhibitors of coagulation factors, computer design of inhibitors, molecular docking

About the authors

N. A. Podoplelova

ORCID iD: 0000-0001-8013-1112
Moscow Russian Federation

V. B. Sulimov

Research Computing Center, Moscow State University;
LLC Dimonta

ORCID iD: 0000-0002-7102-6107
Moscow Russian Federation

I. S. Ilin

Research Computing Center, Moscow State University;
LLC Dimonta

ORCID iD: 0000-0001-8701-5472
Moscow Russian Federation

A. S. Tashilova

Research Computing Center, Moscow State University;
LLC Dimonta

ORCID iD: 0000-0002-3612-393X
Moscow Russian Federation

M. A. Panteleev

Russian Children's Clinical Hospital of the Pirogov Russian National Research Medical University of the Ministry of Healthcare of the Russian Federation;
Center for Theoretical Problems of Physicochemical Pharmakology;
Lomonosov Moscow State University;
Moscow Institute of Physics and Technology (State University)

Author for correspondence.
Email: mapanteleev@yandex.ru
ORCID iD: 0000-0002-8128-7757

PhD, DSc, Head of the Laboratory of cellular hemostasis and trombosis,

117997, Moscow, Samory Mashela st., 1

Russian Federation